Inflammatory proteins and miRNA-144-5p in patients with depression, anxiety, or stress- and adjustment disorders after psychological treatment

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Abstract

Both inflammatory proteins and microRNAs (miRNA) have been reported to be associated with various psychiatric disorders. However, the association between inflammatory proteins and miRNAs remains largely unknown, especially for patients with depression, anxiety, or stress- and adjustment disorders. In this study, we analyzed plasma levels of 92 inflammatory proteins from 178 patients with depression, anxiety, or stress- and adjustment disorders at baseline and after 8-week psychological treatments which resulted in a significant decrease in the Montgomery Åsberg Depression Rating Scale (MADRS-S) score. We investigated the response of the proteins after treatment and the correlation with miR-144-5p. After Benjamini-Hochberg correction for multiple testing, a total of 36 inflammatory proteins changed significantly after 8-week psychological treatments. Among the 36 significantly changed proteins, 21 proteins showed a decrease, and 17/21 proteins were inversely associated with plasma miR-144-5p levels at baseline. In addition, decreases in these proteins were associated with increases in miR-144-5p after treatment. The findings were similar after stratification by use of medications. The associations between the proteins and depression at baseline, measured by MADRS-S, as well as the change in protein levels and treatment response were, however, less clear. These findings need to be examined in future studies.

Original languageEnglish
Article number155646
JournalCytokine
Volume146
DOIs
Publication statusPublished - 2021 Oct

Bibliographical note

Funding Information:
This project was supported by the Swedish Research Council as well as ALF funding from Region Skåne awarded to Jan Sundquist and Kristina Sundquist.

Funding Information:
We would like to thank science editor Patrick Reilly for critical reading of the manuscript as well as to biomedical analyst Anna Hedelius for support in the lab. In addition, the authors wish to thank the County Council in Region Sk?ne for providing financial and administrative support for this study. KS: designed, wrote and edited the final manuscript. KP: analyzed the data, wrote and edited the final manuscript. AAM: collaborated on the design and execution of the study, writing and editing the final manuscript. JS: collaborated on the design, writing and editing of the final manuscript. XW: designed and lead the study, contributed to the data analysis and wrote the paper. This project was supported by the Swedish Research Council as well as ALF funding from Region Sk?ne awarded to Jan Sundquist and Kristina Sundquist.

Publisher Copyright:
© 2021

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

Subject classification (UKÄ)

  • Neurology
  • Psychiatry

Keywords

  • Anxiety
  • Cognitive behavioral therapy
  • Depression
  • Inflammatory proteins
  • Stress and Adjustment Disorders Mindfulness-based therapy

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