Abstract
Aims: To investigate if the presence of factor V Leiden has an influence on the prognosis in central retinal vein occlusion (CRVO).
Methods: 166 patients with CRVO were studied retrospectively. They were tested for factor V Leiden using DNA analysis. The presence of the mutation was studied in correlation with the development of neovascular complications 1 year after the thrombotic event.
Results: 56 of 166 patients (34%) developed neovascular complications after 1 year. In the patients who had the studied mutation 11 of 20 (55%) had developed neovascular complications after 1 year, compared to 45 of 146 patients (31%) in the group without factor V Leiden (p=0.04).
Conclusion: The presence of factor V Leiden seems to enhance the risk of developing neovascular complications in CRVO.
Methods: 166 patients with CRVO were studied retrospectively. They were tested for factor V Leiden using DNA analysis. The presence of the mutation was studied in correlation with the development of neovascular complications 1 year after the thrombotic event.
Results: 56 of 166 patients (34%) developed neovascular complications after 1 year. In the patients who had the studied mutation 11 of 20 (55%) had developed neovascular complications after 1 year, compared to 45 of 146 patients (31%) in the group without factor V Leiden (p=0.04).
Conclusion: The presence of factor V Leiden seems to enhance the risk of developing neovascular complications in CRVO.
| Original language | English |
|---|---|
| Pages (from-to) | 305-306 |
| Journal | British Journal of Ophthalmology |
| Volume | 87 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2003 |
Subject classification (UKÄ)
- Ophthalmology
- Medicinal Chemistry