Inhaled dsRNA and rhinovirus evoke neutrophilic exacerbation and lung expression of thymic stromal lymphopoietin in allergic mice with established experimental asthma.

Irma Mahmutovic Persson, Hamid Akbarshahi, N W Bartlett, N Glanville, S L Johnston, Angelica Brandelius, Lena Uller

Research output: Contribution to journalArticlepeer-review

34 Citations (SciVal)

Abstract

Rhinovirus infection or dsRNA stimulation increased thymic stromal lymphopoietin (TSLP), an upstream pro-allergic cytokine, in asthmatic bronchial epithelial cells. We hypothesized that dsRNA challenges superimposed on established experimental allergic asthma constitute a useful exacerbation model. We further hypothesized that TSLP is induced at dsRNA- and rhinoviral infection-induced exacerbations.
Original languageEnglish
Pages (from-to)348-358
JournalAllergy
Volume69
Issue number3
DOIs
Publication statusPublished - 2014

Subject classification (UKÄ)

  • Respiratory Medicine and Allergy

Fingerprint

Dive into the research topics of 'Inhaled dsRNA and rhinovirus evoke neutrophilic exacerbation and lung expression of thymic stromal lymphopoietin in allergic mice with established experimental asthma.'. Together they form a unique fingerprint.

Cite this