Inhaled dsRNA and rhinovirus evoke neutrophilic exacerbation and lung expression of thymic stromal lymphopoietin in allergic mice with established experimental asthma.

Irma Mahmutovic Persson; Hamid Akbarshahi; N W Bartlett; N Glanville; S L Johnston; Angelica Brandelius; Lena Uller

doi:10.1111/all.12329

Inhaled dsRNA and rhinovirus evoke neutrophilic exacerbation and lung expression of thymic stromal lymphopoietin in allergic mice with established experimental asthma.

Irma Mahmutovic Persson, Hamid Akbarshahi, N W Bartlett, N Glanville, S L Johnston, Angelica Brandelius, Lena Uller

Respiratory Immunopharmacology

Research output: Contribution to journal › Article › peer-review

Abstract

Rhinovirus infection or dsRNA stimulation increased thymic stromal lymphopoietin (TSLP), an upstream pro-allergic cytokine, in asthmatic bronchial epithelial cells. We hypothesized that dsRNA challenges superimposed on established experimental allergic asthma constitute a useful exacerbation model. We further hypothesized that TSLP is induced at dsRNA- and rhinoviral infection-induced exacerbations.

Original language	English
Pages (from-to)	348-358
Journal	Allergy
Volume	69
Issue number	3
DOIs	https://doi.org/10.1111/all.12329
Publication status	Published - 2014

Subject classification (UKÄ)

Respiratory Medicine and Allergy

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10.1111/all.12329

http://www.ncbi.nlm.nih.gov/pubmed/24283976?dopt=Abstract

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title = "Inhaled dsRNA and rhinovirus evoke neutrophilic exacerbation and lung expression of thymic stromal lymphopoietin in allergic mice with established experimental asthma.",

abstract = "Rhinovirus infection or dsRNA stimulation increased thymic stromal lymphopoietin (TSLP), an upstream pro-allergic cytokine, in asthmatic bronchial epithelial cells. We hypothesized that dsRNA challenges superimposed on established experimental allergic asthma constitute a useful exacerbation model. We further hypothesized that TSLP is induced at dsRNA- and rhinoviral infection-induced exacerbations.",

author = "\{Mahmutovic Persson\}, Irma and Hamid Akbarshahi and Bartlett, \{N W\} and N Glanville and Johnston, \{S L\} and Angelica Brandelius and Lena Uller",

year = "2014",

doi = "10.1111/all.12329",

language = "English",

volume = "69",

pages = "348--358",

journal = "Allergy",

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T1 - Inhaled dsRNA and rhinovirus evoke neutrophilic exacerbation and lung expression of thymic stromal lymphopoietin in allergic mice with established experimental asthma.

AU - Mahmutovic Persson, Irma

AU - Akbarshahi, Hamid

AU - Bartlett, N W

AU - Glanville, N

AU - Johnston, S L

AU - Brandelius, Angelica

AU - Uller, Lena

PY - 2014

Y1 - 2014

N2 - Rhinovirus infection or dsRNA stimulation increased thymic stromal lymphopoietin (TSLP), an upstream pro-allergic cytokine, in asthmatic bronchial epithelial cells. We hypothesized that dsRNA challenges superimposed on established experimental allergic asthma constitute a useful exacerbation model. We further hypothesized that TSLP is induced at dsRNA- and rhinoviral infection-induced exacerbations.

AB - Rhinovirus infection or dsRNA stimulation increased thymic stromal lymphopoietin (TSLP), an upstream pro-allergic cytokine, in asthmatic bronchial epithelial cells. We hypothesized that dsRNA challenges superimposed on established experimental allergic asthma constitute a useful exacerbation model. We further hypothesized that TSLP is induced at dsRNA- and rhinoviral infection-induced exacerbations.

UR - https://www.scopus.com/pages/publications/84894267969

U2 - 10.1111/all.12329

DO - 10.1111/all.12329

M3 - Article

C2 - 24283976

SN - 1398-9995

VL - 69

SP - 348

EP - 358

JO - Allergy

JF - Allergy

IS - 3

ER -

Inhaled dsRNA and rhinovirus evoke neutrophilic exacerbation and lung expression of thymic stromal lymphopoietin in allergic mice with established experimental asthma.

Abstract

Subject classification (UKÄ)

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Translational studies of viral-induced asthma and COPD exacerbations

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