Inhibition of Galectins with Small Molecules

Christopher Öberg, Hakon Leffler, Ulf Nilsson

Research output: Contribution to journalArticlepeer-review

57 Citations (SciVal)

Abstract

Evidence that the galectin family of proteins plays crucial roles in cancer, inflammation, and immunity has accumulated over the last decade. The galectins have consequently emerged as interesting drug targets. A majority of galectin functions occurs by means of cross-linking glycoproteins and by doing so controlling gly-coproteirl cellular localization and residence times. The glycoprotein cross-linking occurs when galectin dimers or multimers, or galectins with two binding sites, bind galactose-containing glycans of the glycoproteins. Such galectin-glycan interactions have been successfully blocked with compounds having multivalent presentation of galactose, lactose, or N-acetyllactosamine, with peptides, and with small carbohydrate (galactose) derivatives. This review summarizes and analyzes attempts to develop efficient and selective small-molecule galectin inhibitors through derivatization of monosaccharides, mainly galactosides, with non-carbohydrate structures that protrude into subsites adjacent to the core-conserved galactose-recognizing site of the galectins.
Original languageEnglish
Pages (from-to)18-23
JournalChimia
Volume65
Issue number1-2
DOIs
Publication statusPublished - 2011

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240), Division of Microbiology, Immunology and Glycobiology - MIG (013025200)

Subject classification (UKÄ)

  • Microbiology in the medical area
  • Immunology in the medical area

Keywords

  • Cancer
  • Galectin
  • Immunity
  • Inflammation
  • Inhibitor

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