Inhibition of kainic acid binding to glutamate receptors by extracts of Gastrodia

Maria Andersson; Ola Bergendorff; Mogens Nielsen; Olov Sterner; Robin Witt; Jinglu Ai; Aiping Lu; An Min Wang

doi:10.1016/0031-9422(94)00771-K

Inhibition of kainic acid binding to glutamate receptors by extracts of Gastrodia

Maria Andersson, Ola Bergendorff, Mogens Nielsen, Olov Sterner, Robin Witt, Jinglu Ai, Aiping Lu, An Min Wang

Research output: Contribution to journal › Article › peer-review

Abstract

S-(4-hydroxybenzyl)glutathione was isolated as the major principle responsible for the inhibition of the in vitro binding of kainic acid to brain glutamate receptors by water extracts of the plant Gastrodia elata. The affinity (IC50 value) of the compound is slightly lower compared to glutamate and glutathione.

Original language	English
Pages (from-to)	835-836
Journal	Phytochemistry
Volume	38
Issue number	4
DOIs	https://doi.org/10.1016/0031-9422(94)00771-K
Publication status	Published - 1995

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Department of Dermatology and Venereology (Lund) (013006000), Organic chemistry (S/LTH) (011001240)

Subject classification (UKÄ)

Dermatology and Venereal Diseases

Access to Document

10.1016/0031-9422(94)00771-K

Cite this

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title = "Inhibition of kainic acid binding to glutamate receptors by extracts of Gastrodia",

abstract = "S-(4-hydroxybenzyl)glutathione was isolated as the major principle responsible for the inhibition of the in vitro binding of kainic acid to brain glutamate receptors by water extracts of the plant Gastrodia elata. The affinity (IC50 value) of the compound is slightly lower compared to glutamate and glutathione.",

author = "Maria Andersson and Ola Bergendorff and Mogens Nielsen and Olov Sterner and Robin Witt and Jinglu Ai and Aiping Lu and Wang, {An Min}",

note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Dermatology and Venereology (Lund) (013006000), Organic chemistry (S/LTH) (011001240)",

year = "1995",

doi = "10.1016/0031-9422(94)00771-K",

language = "English",

volume = "38",

pages = "835--836",

journal = "Phytochemistry",

issn = "0031-9422",

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T1 - Inhibition of kainic acid binding to glutamate receptors by extracts of Gastrodia

AU - Andersson, Maria

AU - Bergendorff, Ola

AU - Nielsen, Mogens

AU - Sterner, Olov

AU - Witt, Robin

AU - Ai, Jinglu

AU - Lu, Aiping

AU - Wang, An Min

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Dermatology and Venereology (Lund) (013006000), Organic chemistry (S/LTH) (011001240)

PY - 1995

Y1 - 1995

N2 - S-(4-hydroxybenzyl)glutathione was isolated as the major principle responsible for the inhibition of the in vitro binding of kainic acid to brain glutamate receptors by water extracts of the plant Gastrodia elata. The affinity (IC50 value) of the compound is slightly lower compared to glutamate and glutathione.

AB - S-(4-hydroxybenzyl)glutathione was isolated as the major principle responsible for the inhibition of the in vitro binding of kainic acid to brain glutamate receptors by water extracts of the plant Gastrodia elata. The affinity (IC50 value) of the compound is slightly lower compared to glutamate and glutathione.

U2 - 10.1016/0031-9422(94)00771-K

DO - 10.1016/0031-9422(94)00771-K

M3 - Article

SN - 0031-9422

VL - 38

SP - 835

EP - 836

JO - Phytochemistry

JF - Phytochemistry

IS - 4

ER -

Inhibition of kainic acid binding to glutamate receptors by extracts of Gastrodia

Abstract

Bibliographical note

Subject classification (UKÄ)

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