Inhibition of leukocyte phagocytosis by serotonin and its possible role in tumor cell destruction

U Nannmark; L Sennerby; Lars Magnus Bjursten; G Skolnik; U Bagge

doi:10.1016/0304-3835(92)90202-7

Inhibition of leukocyte phagocytosis by serotonin and its possible role in tumor cell destruction

U Nannmark, L Sennerby, Lars Magnus Bjursten, G Skolnik, U Bagge

External Organization - Unknown

Research output: Contribution to journal › Article › peer-review

Abstract

Intraportal tumour cell (TC) injection activates platelets which release serotonin (5-HT). Thrombocytopenia or 5-HT blockade decrease the hepatic lodgement of the injected TCs. A hypothetical explanation of this is 5-HT inhibition of TC killing by phagocytes (e.g. leukocytes and Kupffer cells). In this study, leukocyte phagocytosis was analysed by a chemiluminescence technique at different 5-HT concentrations. Significant inhibition of phagocytosis occurred at 5-HT concentrations of 10(-4) M to 10(-8) M, with maximum inhibition at 10(-4) M. Comparable concentrations of 5-HT may be found locally in the liver during TC infusion, supporting the hypothesis that 5-HT has an inhibitory effect on phagocyte-mediated TC killing.

Original language	English
Pages (from-to)	83-86
Journal	Cancer Letters
Volume	62
Issue number	1
DOIs	https://doi.org/10.1016/0304-3835(92)90202-7
Publication status	Published - 1992
Externally published	Yes

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Bioimplant Research (013242910)

Subject classification (UKÄ)

Cancer and Oncology

Free keywords

lodgement
phagocytes
tumour cells
liver
serotonin (5-HT)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/0304-3835(92)90202-7

Cite this

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title = "Inhibition of leukocyte phagocytosis by serotonin and its possible role in tumor cell destruction",

abstract = "Intraportal tumour cell (TC) injection activates platelets which release serotonin (5-HT). Thrombocytopenia or 5-HT blockade decrease the hepatic lodgement of the injected TCs. A hypothetical explanation of this is 5-HT inhibition of TC killing by phagocytes (e.g. leukocytes and Kupffer cells). In this study, leukocyte phagocytosis was analysed by a chemiluminescence technique at different 5-HT concentrations. Significant inhibition of phagocytosis occurred at 5-HT concentrations of 10(-4) M to 10(-8) M, with maximum inhibition at 10(-4) M. Comparable concentrations of 5-HT may be found locally in the liver during TC infusion, supporting the hypothesis that 5-HT has an inhibitory effect on phagocyte-mediated TC killing.",

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author = "U Nannmark and L Sennerby and Bjursten, {Lars Magnus} and G Skolnik and U Bagge",

note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Bioimplant Research (013242910)",

year = "1992",

doi = "10.1016/0304-3835(92)90202-7",

language = "English",

volume = "62",

pages = "83--86",

journal = "Cancer Letters",

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TY - JOUR

T1 - Inhibition of leukocyte phagocytosis by serotonin and its possible role in tumor cell destruction

AU - Nannmark, U

AU - Sennerby, L

AU - Bjursten, Lars Magnus

AU - Skolnik, G

AU - Bagge, U

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Bioimplant Research (013242910)

PY - 1992

Y1 - 1992

N2 - Intraportal tumour cell (TC) injection activates platelets which release serotonin (5-HT). Thrombocytopenia or 5-HT blockade decrease the hepatic lodgement of the injected TCs. A hypothetical explanation of this is 5-HT inhibition of TC killing by phagocytes (e.g. leukocytes and Kupffer cells). In this study, leukocyte phagocytosis was analysed by a chemiluminescence technique at different 5-HT concentrations. Significant inhibition of phagocytosis occurred at 5-HT concentrations of 10(-4) M to 10(-8) M, with maximum inhibition at 10(-4) M. Comparable concentrations of 5-HT may be found locally in the liver during TC infusion, supporting the hypothesis that 5-HT has an inhibitory effect on phagocyte-mediated TC killing.

AB - Intraportal tumour cell (TC) injection activates platelets which release serotonin (5-HT). Thrombocytopenia or 5-HT blockade decrease the hepatic lodgement of the injected TCs. A hypothetical explanation of this is 5-HT inhibition of TC killing by phagocytes (e.g. leukocytes and Kupffer cells). In this study, leukocyte phagocytosis was analysed by a chemiluminescence technique at different 5-HT concentrations. Significant inhibition of phagocytosis occurred at 5-HT concentrations of 10(-4) M to 10(-8) M, with maximum inhibition at 10(-4) M. Comparable concentrations of 5-HT may be found locally in the liver during TC infusion, supporting the hypothesis that 5-HT has an inhibitory effect on phagocyte-mediated TC killing.

KW - lodgement

KW - phagocytes

KW - tumour cells

KW - liver

KW - serotonin (5-HT)

U2 - 10.1016/0304-3835(92)90202-7

DO - 10.1016/0304-3835(92)90202-7

M3 - Article

SN - 1872-7980

VL - 62

SP - 83

EP - 86

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

Inhibition of leukocyte phagocytosis by serotonin and its possible role in tumor cell destruction

Abstract

Bibliographical note

Subject classification (UKÄ)

Free keywords

UN SDGs

Access to Document

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