Abstract
Two flavones, 4',5,7-trihydroxy-6-methoxy flavone (dinatin) and 4',5-dihydroxy-6, 7-dimethoxy flavone (skrofulein), were extracted from Artemisia herba alba L. Dinatin and skrofulein inhibited the binding of [methyl-3H]diazepam to rat brain membranes in vitro with IC50 of 1.3 and 23 mumol.L-1, respectively. The GABA-ratios (the ratio of IC50 values in the absence/presence of GABA in the binding assay) were 1.1 and 1.2 for dinatin and skrofulein, respectively. Both flavones induced a slight increase in [35S] TBPS binding. The data suggest that the flavones are antagonists or partial agonists of benzodiazepine receptors.
| Original language | English |
|---|---|
| Pages (from-to) | 385-388 |
| Journal | Zhongguo Yaoli Xuebao (China) |
| Volume | 15 |
| Issue number | 5 |
| Publication status | Published - 1994 |
Bibliographical note
The information about affiliations in this record was updated in December 2015.The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240), Department of Dermatology and Venereology (Lund) (013006000)
Subject classification (UKÄ)
- Dermatology and Venereal Diseases