Inhibition of [methyl-3H]diazepam binding to rat brain membranes in vitro by dinatin and skrofulein

X L Shen, M Nielsen, M R Witt, Olov Sterner, Ola Bergendorff, M Khayyal

Research output: Contribution to journalArticlepeer-review


Two flavones, 4',5,7-trihydroxy-6-methoxy flavone (dinatin) and 4',5-dihydroxy-6, 7-dimethoxy flavone (skrofulein), were extracted from Artemisia herba alba L. Dinatin and skrofulein inhibited the binding of [methyl-3H]diazepam to rat brain membranes in vitro with IC50 of 1.3 and 23 mumol.L-1, respectively. The GABA-ratios (the ratio of IC50 values in the absence/presence of GABA in the binding assay) were 1.1 and 1.2 for dinatin and skrofulein, respectively. Both flavones induced a slight increase in [35S] TBPS binding. The data suggest that the flavones are antagonists or partial agonists of benzodiazepine receptors.
Original languageEnglish
Pages (from-to)385-388
JournalZhongguo Yaoli Xuebao (China)
Issue number5
Publication statusPublished - 1994

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240), Department of Dermatology and Venereology (Lund) (013006000)

Subject classification (UKÄ)

  • Dermatology and Venereal Diseases


Dive into the research topics of 'Inhibition of [methyl-3H]diazepam binding to rat brain membranes in vitro by dinatin and skrofulein'. Together they form a unique fingerprint.

Cite this