Inhibition of mitotic kinase Mps1 promotes cell death in neuroblastoma

Research output: Contribution to journalArticlepeer-review

1 Citation (SciVal)

Abstract

Neuroblastoma is the most common paediatric cancer type. Patients diagnosed with high-risk neuroblastoma have poor prognosis and occasionally tumours relapse. As a result, novel treatment strategies are needed for relapse and refractory neuroblastoma patients. Here, we found that high expression of Mps1 kinase (mitotic kinase Monopolar Spindle 1) was associated with relapse-free neuroblastoma patient outcomes and poor overall survival. Silencing and inhibition of Mps1 in neuroblastoma or PDX-derived cells promoted cell apoptosis via the caspase-dependent mitochondrial apoptotic pathway. The mechanism of cell death upon Mps1 inhibition was dependent on the polyploidization/aneuploidization of the cells before undergoing mitotic catastrophe. Furthermore, tumour growth retardation was confirmed in a xenograft mouse model after Mps1-inhibitor treatment. Altogether, these results suggest that Mps1 expression and inhibition can be considered as a novel prognostic marker as well as a therapeutic strategy for the treatment of high-risk neuroblastoma patients.

Original languageEnglish
Pages (from-to)11997
JournalScientific Reports
Volume10
Issue number1
DOIs
Publication statusPublished - 2020 Jul 20

Bibliographical note

These authors jointly supervised this work: Ramin Massoumi and Mohamed Jemaà.

Subject classification (UKÄ)

  • Cancer and Oncology

Fingerprint

Dive into the research topics of 'Inhibition of mitotic kinase Mps1 promotes cell death in neuroblastoma'. Together they form a unique fingerprint.

Cite this