Inhibition of nuclear factor of activated T-cells (NFAT) suppresses accelerated atherosclerosis in diabetic mice.

Anna Zetterqvist, Lisa Berglund, Fabiana Blanco, Eliana Garcia Vaz, Maria Wigren, Pontus Dunér, Anna-Maria Dutius Andersson, Fong To, Peter Spégel, Jan Nilsson, Eva Bengtsson, Maria Gomez

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Abstract

Diabetic patients have a much more widespread and aggressive form of atherosclerosis and therefore, higher risk for myocardial infarction, peripheral vascular disease and stroke, but the molecular mechanisms leading to accelerated damage are still unclear. Recently, we showed that hyperglycemia activates the transcription factor NFAT in the arterial wall, inducing the expression of the pro-atherosclerotic protein osteopontin. Here we investigate whether NFAT activation may be a link between diabetes and atherogenesis.
Original languageEnglish
Article numbere65020
JournalPLoS ONE
Volume8
Issue number6
DOIs
Publication statusPublished - 2013

Subject classification (UKÄ)

  • Cardiac and Cardiovascular Systems
  • Clinical Medicine
  • Endocrinology and Diabetes

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