Innate and adaptive immunity in immune thrombocytopenia

Alan H Lazarus; John W Semple; Douglas B Cines

doi:10.1053/j.seminhematol.2013.03.012

Innate and adaptive immunity in immune thrombocytopenia

Alan H Lazarus, John W Semple, Douglas B Cines

University of Toronto

Research output: Contribution to journal › Article › peer-review

Abstract

Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by both accelerated clearance of autoantibody-sensitized platelets and suboptimal platelet production. A number of studies have provided evidence of disturbed innate and adaptive immune responses in patients with ITP. This brief review will highlight some of the more recent work in this field and highlight other findings that provide a potential link between ITP, systemic lupus erythematosus (SLE), and autoimmune hemolytic anemia (AHA).

Original language	English
Pages (from-to)	S68-70
Journal	Seminars in Hematology
Volume	50
Issue number	Suppl 1
DOIs	https://doi.org/10.1053/j.seminhematol.2013.03.012
Publication status	Published - 2013 Jan
Externally published	Yes

Free keywords

Adaptive Immunity
Animals
Humans
Immunity, Innate
Thrombocytopenia
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

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10.1053/j.seminhematol.2013.03.012

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title = "Innate and adaptive immunity in immune thrombocytopenia",

abstract = "Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by both accelerated clearance of autoantibody-sensitized platelets and suboptimal platelet production. A number of studies have provided evidence of disturbed innate and adaptive immune responses in patients with ITP. This brief review will highlight some of the more recent work in this field and highlight other findings that provide a potential link between ITP, systemic lupus erythematosus (SLE), and autoimmune hemolytic anemia (AHA).",

keywords = "Adaptive Immunity, Animals, Humans, Immunity, Innate, Thrombocytopenia, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review",

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AU - Semple, John W

AU - Cines, Douglas B

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AB - Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by both accelerated clearance of autoantibody-sensitized platelets and suboptimal platelet production. A number of studies have provided evidence of disturbed innate and adaptive immune responses in patients with ITP. This brief review will highlight some of the more recent work in this field and highlight other findings that provide a potential link between ITP, systemic lupus erythematosus (SLE), and autoimmune hemolytic anemia (AHA).

KW - Adaptive Immunity

KW - Animals

KW - Humans

KW - Immunity, Innate

KW - Thrombocytopenia

KW - Journal Article

KW - Research Support, N.I.H., Extramural

KW - Research Support, Non-U.S. Gov't

KW - Review

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DO - 10.1053/j.seminhematol.2013.03.012

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SP - S68-70

JO - Seminars in Hematology

JF - Seminars in Hematology

IS - Suppl 1

ER -

Innate and adaptive immunity in immune thrombocytopenia

Abstract

Free keywords

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