iNOS affects matrix production in distal lung fibroblasts from patients with mild asthma.

Anna-Karin Larsson Callerfelt; Maria Weitoft; Kristian Nihlberg; Leif Bjermer; Gunilla Westergren-Thorsson; Ellen Tufvesson

doi:10.1016/j.pupt.2015.09.003

iNOS affects matrix production in distal lung fibroblasts from patients with mild asthma.

Anna-Karin Larsson Callerfelt, Maria Weitoft, Kristian Nihlberg, Leif Bjermer, Gunilla Westergren-Thorsson, Ellen Tufvesson

Research output: Contribution to journal › Review article › peer-review

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Abstract

A high level of exhaled nitric oxide (NO) is a marker for inflammation in the airways of asthmatic subjects. However, little is known about how NO and inducible nitric oxides synthase (iNOS) activity may affect remodelling in the distal lung. We hypothesized that there is a link between iNOS and ongoing remodelling processes in the distal lung of mild asthmatics.

Original language	English
Pages (from-to)	64-71
Journal	Pulmonary Pharmacology & Therapeutics
Volume	34
Issue number	sep 9
DOIs	https://doi.org/10.1016/j.pupt.2015.09.003
Publication status	Published - 2015

Subject classification (UKÄ)

Respiratory Medicine and Allergy

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10.1016/j.pupt.2015.09.003

Elsevier Larsson Callerfelt et alAccepted author manuscript, 475 KB

http://www.ncbi.nlm.nih.gov/pubmed/26362859?dopt=Abstract

1 Doctoral Thesis (compilation)

Extracellular Matrix Alterations in Patients with Different Phenotypes of Asthma.
Weitoft, M., 2017, Lund: Lund University: Faculty of Medicine. 76 p.
Research output: Thesis › Doctoral Thesis (compilation)

Cite this

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title = "iNOS affects matrix production in distal lung fibroblasts from patients with mild asthma.",

abstract = "A high level of exhaled nitric oxide (NO) is a marker for inflammation in the airways of asthmatic subjects. However, little is known about how NO and inducible nitric oxides synthase (iNOS) activity may affect remodelling in the distal lung. We hypothesized that there is a link between iNOS and ongoing remodelling processes in the distal lung of mild asthmatics.",

author = "{Larsson Callerfelt}, Anna-Karin and Maria Weitoft and Kristian Nihlberg and Leif Bjermer and Gunilla Westergren-Thorsson and Ellen Tufvesson",

year = "2015",

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language = "English",

volume = "34",

pages = "64--71",

journal = "Pulmonary Pharmacology & Therapeutics",

issn = "1522-9629",

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T1 - iNOS affects matrix production in distal lung fibroblasts from patients with mild asthma.

AU - Larsson Callerfelt, Anna-Karin

AU - Weitoft, Maria

AU - Nihlberg, Kristian

AU - Bjermer, Leif

AU - Westergren-Thorsson, Gunilla

AU - Tufvesson, Ellen

PY - 2015

Y1 - 2015

N2 - A high level of exhaled nitric oxide (NO) is a marker for inflammation in the airways of asthmatic subjects. However, little is known about how NO and inducible nitric oxides synthase (iNOS) activity may affect remodelling in the distal lung. We hypothesized that there is a link between iNOS and ongoing remodelling processes in the distal lung of mild asthmatics.

AB - A high level of exhaled nitric oxide (NO) is a marker for inflammation in the airways of asthmatic subjects. However, little is known about how NO and inducible nitric oxides synthase (iNOS) activity may affect remodelling in the distal lung. We hypothesized that there is a link between iNOS and ongoing remodelling processes in the distal lung of mild asthmatics.

U2 - 10.1016/j.pupt.2015.09.003

DO - 10.1016/j.pupt.2015.09.003

M3 - Review article

C2 - 26362859

SN - 1522-9629

VL - 34

SP - 64

EP - 71

JO - Pulmonary Pharmacology & Therapeutics

JF - Pulmonary Pharmacology & Therapeutics

IS - sep 9

ER -

iNOS affects matrix production in distal lung fibroblasts from patients with mild asthma.

Abstract

Subject classification (UKÄ)

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Research output

Extracellular Matrix Alterations in Patients with Different Phenotypes of Asthma.

Cite this