Insulin secretion: The nitric oxide controversy

Sevda Gheibi, Asghar Ghasemi

Research output: Contribution to journalReview articlepeer-review

8 Citations (SciVal)


Nitric oxide (NO) is a gas that serves as a ubiquitous signaling molecule participating in physiological activities of various organ systems. Nitric oxide is produced in the endocrine pancreas and contributes to synthesis and secretion of insulin. The potential role of NO in insulin secretion is disputable – both stimulatory and inhibitory effects have been reported. Available data indicate that effects of NO critically depend on its concentration. Different isoforms of NO synthase (NOS) control this and have the potential to decrease or increase insulin secretion. In this review, the role of NO in insulin secretion as well as the possible reasons for discrepant findings are dis-cussed. A better understanding of the role of NO system in the regulation of insulin secretion may facilitate the development of new therapeutic strategies in the management of diabetes.

Original languageEnglish
Pages (from-to)1227-1245
Number of pages19
JournalEXCLI Journal
Publication statusPublished - 2020

Subject classification (UKÄ)

  • Endocrinology and Diabetes


  • Insulin secretion
  • Insulin synthesis
  • Nitric oxide


Dive into the research topics of 'Insulin secretion: The nitric oxide controversy'. Together they form a unique fingerprint.

Cite this