Intakes of omega-3 polyunsaturated fatty acids and blood pressure change over time: Possible interaction with genes involved in 20-HETE and EETs metabolism.

Angela Tagetti, Ulrika Ericson, Martina Montagnana, Elisa Danese, Peter Almgren, Peter Nilsson, Gunnar Engström, Bo Hedblad, Pietro Minuz, Marju Orho-Melander, Cristiano Fava, Olle Melander

Research output: Contribution to journalArticlepeer-review

17 Citations (SciVal)

Abstract

A high intake of omega-3 polyunsaturated fatty acids (ω-3 PUFAs), has been associated with reduced levels of blood pressure (BP). Their antihypertensive action may be due to the reduction of the ω-6/ω-3 ratio and the resulting competitive effect of ω-3 as compared to arachidonic acid (an ω-6 PUFA) as a substrate of cytochrome P450 (CYP450) enzymes involved in the production of vasoactive mediators. Some functional polymorphisms (SNPs), in genes which encode for the same enzymes, were associated with hypertension and ischemic stroke in the Malmö Diet and Cancer (MDC), a Swedish urban-based longitudinal study. The aim of this study was to evaluate the effect of the intake of different types of PUFAs on BP change over time (Δ-BP; mean follow-up 16.6±1.5 years; n=3.550 with complete phenotypic data), also considering the interaction with SNPs in genes involved in their metabolism via CYP450.
Original languageEnglish
Pages (from-to)126-133
JournalProstaglandins & other Lipid Mediators
Volume120
Issue numberMay 16
DOIs
Publication statusPublished - 2015

Subject classification (UKÄ)

  • Endocrinology and Diabetes
  • Cardiac and Cardiovascular Systems

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