Integrating disease knowledge and technology to deliver protein targets and biomarkers into drug discovery projects

Thomas E. Fehniger, Thomas Laurell, György Marko-Varga

Research output: Contribution to journalArticlepeer-review

Abstract

Biomarker discovery is dependent upon two disciplines: the field of clinical bioanalysis linked to disease aetiology and the application of high level technology platforms for identifying proteins/peptides in complex samples. However, diagnostic biomarker measurements require certain definitions of context that can only be achieved by combining protein science with clinical science. The evaluation of biomarkers requires careful attention to match (1) a specific biological question with (2) the appropriate clinical sample and (3) high resolution technology systems which link protein identities to clinical informatics.
Original languageEnglish
Pages (from-to)345-351
JournalDrug Discovery Today: Technologies
Volume2
Issue number4
DOIs
Publication statusPublished - 2005

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Biomedical Engineering (011200011), Analytical Chemistry (S/LTH) (011001004)

Subject classification (UKÄ)

  • Analytical Chemistry
  • Medical Engineering

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