International Standard reagents for harmonization of HPV serology and DNA assays - an update

Sonia R. Pagliusi; Joakim Dillner; Michael Pawlita; Wim G. V. Quint; Cosette M. Wheeler; M. Ferguson

doi:10.1016/j.vaccine.2006.06.016

International Standard reagents for harmonization of HPV serology and DNA assays - an update

Sonia R. Pagliusi, Joakim Dillner, Michael Pawlita, Wim G. V. Quint, Cosette M. Wheeler, M. Ferguson

Clinical Microbiology, Malmö

Research output: Contribution to journal › Article › peer-review

Abstract

International reference materials such as International Standard reagents facilitate quality assurance of essential biopharmaceutical products and related in vitro diagnostic tests. Standardization of antibody and DNA measurements and harmonization of laboratory procedures are key to the success of cancer prevention strategies through screening methods as well as for development and implementation of vaccination against the human papillomavirus (HPV). The WHO supported the preparation and initial analysis of a panel of candidate serological and DNA reference reagents aimed at facilitating inter-laboratory comparisons and detection of HPV worldwide. Two international collaborative studies assessed the performance of various HPV antibody and HPV-DNA detection assays and examined the feasibility of generating HPV antibody and DNA standard reagents. These studies showed that improvement in performance and comparability of assays is urgently needed and that the use of the same International Standard reference reagent could significantly improve performance and comparability. It is hoped that the establishment of International Units and International Standards for HPV antibody and DNA analysis will be pursued with high priority. (c) 2006 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	193-200
Journal	Vaccine
Volume	24
Issue number	Suppl. 3
DOIs	https://doi.org/10.1016/j.vaccine.2006.06.016
Publication status	Published - 2006

Subject classification (UKÄ)

Microbiology in the medical area

Free keywords

assays
DNA evaluation
HPV
serological

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.vaccine.2006.06.016

Cite this

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title = "International Standard reagents for harmonization of HPV serology and DNA assays - an update",

abstract = "International reference materials such as International Standard reagents facilitate quality assurance of essential biopharmaceutical products and related in vitro diagnostic tests. Standardization of antibody and DNA measurements and harmonization of laboratory procedures are key to the success of cancer prevention strategies through screening methods as well as for development and implementation of vaccination against the human papillomavirus (HPV). The WHO supported the preparation and initial analysis of a panel of candidate serological and DNA reference reagents aimed at facilitating inter-laboratory comparisons and detection of HPV worldwide. Two international collaborative studies assessed the performance of various HPV antibody and HPV-DNA detection assays and examined the feasibility of generating HPV antibody and DNA standard reagents. These studies showed that improvement in performance and comparability of assays is urgently needed and that the use of the same International Standard reference reagent could significantly improve performance and comparability. It is hoped that the establishment of International Units and International Standards for HPV antibody and DNA analysis will be pursued with high priority. (c) 2006 Elsevier Ltd. All rights reserved.",

keywords = "assays, DNA evaluation, HPV, serological",

author = "Pagliusi, {Sonia R.} and Joakim Dillner and Michael Pawlita and Quint, {Wim G. V.} and Wheeler, {Cosette M.} and M. Ferguson",

year = "2006",

doi = "10.1016/j.vaccine.2006.06.016",

language = "English",

volume = "24",

pages = "193--200",

journal = "Vaccine",

issn = "1873-2518",

publisher = "Elsevier",

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T1 - International Standard reagents for harmonization of HPV serology and DNA assays - an update

AU - Pagliusi, Sonia R.

AU - Dillner, Joakim

AU - Pawlita, Michael

AU - Quint, Wim G. V.

AU - Wheeler, Cosette M.

AU - Ferguson, M.

PY - 2006

Y1 - 2006

N2 - International reference materials such as International Standard reagents facilitate quality assurance of essential biopharmaceutical products and related in vitro diagnostic tests. Standardization of antibody and DNA measurements and harmonization of laboratory procedures are key to the success of cancer prevention strategies through screening methods as well as for development and implementation of vaccination against the human papillomavirus (HPV). The WHO supported the preparation and initial analysis of a panel of candidate serological and DNA reference reagents aimed at facilitating inter-laboratory comparisons and detection of HPV worldwide. Two international collaborative studies assessed the performance of various HPV antibody and HPV-DNA detection assays and examined the feasibility of generating HPV antibody and DNA standard reagents. These studies showed that improvement in performance and comparability of assays is urgently needed and that the use of the same International Standard reference reagent could significantly improve performance and comparability. It is hoped that the establishment of International Units and International Standards for HPV antibody and DNA analysis will be pursued with high priority. (c) 2006 Elsevier Ltd. All rights reserved.

AB - International reference materials such as International Standard reagents facilitate quality assurance of essential biopharmaceutical products and related in vitro diagnostic tests. Standardization of antibody and DNA measurements and harmonization of laboratory procedures are key to the success of cancer prevention strategies through screening methods as well as for development and implementation of vaccination against the human papillomavirus (HPV). The WHO supported the preparation and initial analysis of a panel of candidate serological and DNA reference reagents aimed at facilitating inter-laboratory comparisons and detection of HPV worldwide. Two international collaborative studies assessed the performance of various HPV antibody and HPV-DNA detection assays and examined the feasibility of generating HPV antibody and DNA standard reagents. These studies showed that improvement in performance and comparability of assays is urgently needed and that the use of the same International Standard reference reagent could significantly improve performance and comparability. It is hoped that the establishment of International Units and International Standards for HPV antibody and DNA analysis will be pursued with high priority. (c) 2006 Elsevier Ltd. All rights reserved.

KW - assays

KW - DNA evaluation

KW - HPV

KW - serological

U2 - 10.1016/j.vaccine.2006.06.016

DO - 10.1016/j.vaccine.2006.06.016

M3 - Article

SN - 1873-2518

VL - 24

SP - 193

EP - 200

JO - Vaccine

JF - Vaccine

IS - Suppl. 3

ER -

International Standard reagents for harmonization of HPV serology and DNA assays - an update

Abstract

Subject classification (UKÄ)

Free keywords

UN SDGs

Access to Document

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Cite this