Interstitial Laser Thermotherapy of Liver Tumours. Methodology and Application

Páll Helgi Möller

Research output: ThesisDoctoral Thesis (compilation)

Abstract

Interstitial laser thermotherapy (ILT) is a method well suited for selective local destruction of malignant tumours. In the present work, a laser thermotherapy system based on feedback temperature control of energy delivery (through computerised feedback system) was developed. Temperature control was excellent in experiments without carbonization and with preserved light penetration, whereas temperature oscillations were in experiments with carbonization and impaired light penetration. Using bare fibre, carbonization was seen in almost all experiments in vitro, regardless of output power (1-4 W) but only occasionally in vivo using 2 W. Treatment with a sapphire prob, representing a diffuser tip, gave carbonization at higher output powers (> 3 W in vitro, > W in vivo). The bare fibre gave a steeper temperature gradient than the sapphire probe. In normal pig liver the volume of thermal damage was increased five times by occluding the blood flow to the liver during treatment. It was not possible to predic
Original languageEnglish
QualificationDoctor
Awarding Institution
  • Surgery (Lund)
Supervisors/Advisors
  • [unknown], [unknown], Supervisor, External person
Award date1997 May 17
Publisher
Publication statusPublished - 2004

Bibliographical note

Defence details

Date: 1997-05-17
Time: 10:15
Place: Lecture room 1, Central Building, University Hospital, Lund

External reviewer(s)

Name: Schröder, Tom
Title: Docent
Affiliation: Helsinki, Finland

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Article: PH Möller, L Lindberg, PH Henriksson, BRR Persson, K-G Tranberg. Temperature control and light penetration in a feedback interstitial laser thermotherapy system.Int J Hyperthermia 12:49-63, 1996.

Article: PH Möller, L Lindberg, PH Henriksson, BRR Persson, K-G Tranberg. Interstitial laser thermotherapy: comparison between bare fibre and sapphire probe.Laser Med Sci 10:193-200, 1995.

Article: K-G Tranberg, PH Möller, P Hannesson, U Stenram. Interstitial laser treatment of malignant tumours: initial experience.Eur J Surg Oncol 22:47-54, 1996.

Article: PH Möller, PH Hannesson, K Ivarsson, J Olsrud, U Stenram, K-G Tranberg. Interstitial laser thermotherapy in pig liver: effect of inflow occlusion on extent of necrosis and ultrasound image.Hepato-Gastroenterology 1996, in press.

Article: PH Möller, K Ivarsson, U Stenram, M Radnell, K-G Tranberg. Interstitial laser thermotherapy of adenocarcinoma transplanted into rat liver.Eur J Surg 1996, in p

Subject classification (UKÄ)

  • Surgery

Free keywords

  • Resection
  • Liver
  • Neoplasm
  • Blood flow
  • Monitoring
  • Feedback control
  • Light penetration
  • Bare fibre
  • Sapphire probe
  • Nd:YAG laser
  • Interstitial thermotherapy
  • Hyperthermia
  • Surgery
  • orthopaedics
  • traumatology
  • Kirurgi
  • ortopedi
  • traumatologi

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