TY - JOUR
T1 - Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer's disease
AU - Gouras, Gunnar K.
AU - Tampellini, Davide
AU - Takahashi, Reisuke H.
AU - Capetillo-Zarate, Estibaliz
PY - 2010/5/1
Y1 - 2010/5/1
N2 - The aberrant accumulation of aggregated β-amyloid peptides (Aβ) as plaques is a hallmark of Alzheimer's disease (AD) neuropathology and reduction of Ab has become a leading direction of emerging experimental therapies for the disease. The mechanism(s) whereby Aβ is involved in the pathophysiology of the disease remain(s) poorly understood. Initially fibrils, and subsequently oligomers of extracellular Aβ have been viewed as the most important pathogenic form of Aβ in AD. More recently, the intraneuronal accumulation of Aβ has been described in the brain, although technical considerations and its relevance in AD have made this a controversial topic. Here, we review the emerging evidence linking intraneuronal Aβ accumulation to the development of synaptic pathology and plaques in AD, and discuss the implications of intraneuronal β-amyloid for AD pathology, biology, diagnosis and therapy.
AB - The aberrant accumulation of aggregated β-amyloid peptides (Aβ) as plaques is a hallmark of Alzheimer's disease (AD) neuropathology and reduction of Ab has become a leading direction of emerging experimental therapies for the disease. The mechanism(s) whereby Aβ is involved in the pathophysiology of the disease remain(s) poorly understood. Initially fibrils, and subsequently oligomers of extracellular Aβ have been viewed as the most important pathogenic form of Aβ in AD. More recently, the intraneuronal accumulation of Aβ has been described in the brain, although technical considerations and its relevance in AD have made this a controversial topic. Here, we review the emerging evidence linking intraneuronal Aβ accumulation to the development of synaptic pathology and plaques in AD, and discuss the implications of intraneuronal β-amyloid for AD pathology, biology, diagnosis and therapy.
KW - Amyloid
KW - Dementia pugilistica
KW - Endosome
KW - Head injury
KW - Synapse
KW - Tau
UR - http://www.scopus.com/inward/record.url?scp=77953019895&partnerID=8YFLogxK
U2 - 10.1007/s00401-010-0679-9
DO - 10.1007/s00401-010-0679-9
M3 - Review article
C2 - 20354705
AN - SCOPUS:77953019895
VL - 119
SP - 523
EP - 541
JO - Acta Neuropathologica
JF - Acta Neuropathologica
SN - 1432-0533
IS - 5
ER -