Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer's disease

Gunnar K. Gouras, Davide Tampellini, Reisuke H. Takahashi, Estibaliz Capetillo-Zarate

Research output: Contribution to journalReview articlepeer-review

272 Citations (SciVal)

Abstract

The aberrant accumulation of aggregated β-amyloid peptides (Aβ) as plaques is a hallmark of Alzheimer's disease (AD) neuropathology and reduction of Ab has become a leading direction of emerging experimental therapies for the disease. The mechanism(s) whereby Aβ is involved in the pathophysiology of the disease remain(s) poorly understood. Initially fibrils, and subsequently oligomers of extracellular Aβ have been viewed as the most important pathogenic form of Aβ in AD. More recently, the intraneuronal accumulation of Aβ has been described in the brain, although technical considerations and its relevance in AD have made this a controversial topic. Here, we review the emerging evidence linking intraneuronal Aβ accumulation to the development of synaptic pathology and plaques in AD, and discuss the implications of intraneuronal β-amyloid for AD pathology, biology, diagnosis and therapy.

Original languageEnglish
Pages (from-to)523-541
JournalActa Neuropathologica
Volume119
Issue number5
DOIs
Publication statusPublished - 2010 May 1
Externally publishedYes

Subject classification (UKÄ)

  • Neurosciences

Keywords

  • Amyloid
  • Dementia pugilistica
  • Endosome
  • Head injury
  • Synapse
  • Tau

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