Intravenous immunoglobulin and anti-D in idiopathic thrombocytopenic purpura (ITP): mechanisms of action

A H Lazarus; J Freedman; J W Semple

doi:10.1016/s0955-3886(98)00043-5

Intravenous immunoglobulin and anti-D in idiopathic thrombocytopenic purpura (ITP): mechanisms of action

A H Lazarus, J Freedman, J W Semple

Saint Michael's Hospital

Research output: Contribution to journal › Review article › peer-review

Abstract

Infusion of large amounts of intravenous immunoglobulin (IVIG) or anti-D can reverse the low platelet count in patients with ITP within hours of the initiation of treatment. In some cases, the effects of IVIG appear to far outlast several half-lives of the product. Several mechanisms have been proposed to explain these rapid and long term effects and these will be discussed in this review.

Original language	English
Pages (from-to)	289-94
Journal	Transfusion Science
Volume	19
Issue number	3
DOIs	https://doi.org/10.1016/s0955-3886(98)00043-5
Publication status	Published - 1998 Sept
Externally published	Yes

Subject classification (UKÄ)

Hematology

Free keywords

Antibodies, Anti-Idiotypic/immunology
Autoantibodies/immunology
Autoimmune Diseases/immunology
Blood Platelets/immunology
Clinical Trials as Topic
Half-Life
Humans
Immunoglobulin G/immunology
Immunoglobulin M/immunology
Immunoglobulins, Intravenous/therapeutic use
Isoantibodies/therapeutic use
Macrophage Activation
Mononuclear Phagocyte System/physiopathology
Purpura, Thrombocytopenic, Idiopathic/immunology
Rho(D) Immune Globulin

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10.1016/s0955-3886(98)00043-5

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title = "Intravenous immunoglobulin and anti-D in idiopathic thrombocytopenic purpura (ITP): mechanisms of action",

abstract = "Infusion of large amounts of intravenous immunoglobulin (IVIG) or anti-D can reverse the low platelet count in patients with ITP within hours of the initiation of treatment. In some cases, the effects of IVIG appear to far outlast several half-lives of the product. Several mechanisms have been proposed to explain these rapid and long term effects and these will be discussed in this review.",

keywords = "Antibodies, Anti-Idiotypic/immunology, Autoantibodies/immunology, Autoimmune Diseases/immunology, Blood Platelets/immunology, Clinical Trials as Topic, Half-Life, Humans, Immunoglobulin G/immunology, Immunoglobulin M/immunology, Immunoglobulins, Intravenous/therapeutic use, Isoantibodies/therapeutic use, Macrophage Activation, Mononuclear Phagocyte System/physiopathology, Purpura, Thrombocytopenic, Idiopathic/immunology, Rho(D) Immune Globulin",

author = "Lazarus, {A H} and J Freedman and Semple, {J W}",

year = "1998",

month = sep,

doi = "10.1016/s0955-3886(98)00043-5",

language = "English",

volume = "19",

pages = "289--94",

journal = "Transfusion Science",

issn = "0955-3886",

publisher = "Pergamon Press Ltd.",

number = "3",

}

TY - JOUR

T1 - Intravenous immunoglobulin and anti-D in idiopathic thrombocytopenic purpura (ITP)

T2 - mechanisms of action

AU - Lazarus, A H

AU - Freedman, J

AU - Semple, J W

PY - 1998/9

Y1 - 1998/9

N2 - Infusion of large amounts of intravenous immunoglobulin (IVIG) or anti-D can reverse the low platelet count in patients with ITP within hours of the initiation of treatment. In some cases, the effects of IVIG appear to far outlast several half-lives of the product. Several mechanisms have been proposed to explain these rapid and long term effects and these will be discussed in this review.

AB - Infusion of large amounts of intravenous immunoglobulin (IVIG) or anti-D can reverse the low platelet count in patients with ITP within hours of the initiation of treatment. In some cases, the effects of IVIG appear to far outlast several half-lives of the product. Several mechanisms have been proposed to explain these rapid and long term effects and these will be discussed in this review.

KW - Antibodies, Anti-Idiotypic/immunology

KW - Autoantibodies/immunology

KW - Autoimmune Diseases/immunology

KW - Blood Platelets/immunology

KW - Clinical Trials as Topic

KW - Half-Life

KW - Humans

KW - Immunoglobulin G/immunology

KW - Immunoglobulin M/immunology

KW - Immunoglobulins, Intravenous/therapeutic use

KW - Isoantibodies/therapeutic use

KW - Macrophage Activation

KW - Mononuclear Phagocyte System/physiopathology

KW - Purpura, Thrombocytopenic, Idiopathic/immunology

KW - Rho(D) Immune Globulin

U2 - 10.1016/s0955-3886(98)00043-5

DO - 10.1016/s0955-3886(98)00043-5

M3 - Review article

C2 - 10351141

SN - 0955-3886

VL - 19

SP - 289

EP - 294

JO - Transfusion Science

JF - Transfusion Science

IS - 3

ER -

Intravenous immunoglobulin and anti-D in idiopathic thrombocytopenic purpura (ITP): mechanisms of action

Abstract

Subject classification (UKÄ)

Free keywords

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