Involvement of eotaxin, eosinophils, and pancreatic predisposition in development of type 1 diabetes mellitus in the BioBreeding rat.

Martin J Hessner, Xujing Wang, Lisa Meyer, Rhonda Geoffrey, Shuang Jia, Jessica Fuller, Åke Lernmark, Soumitra Ghosh

Research output: Contribution to journalArticlepeer-review

50 Citations (SciVal)

Abstract

Allergy and autoimmunity are both examples of deregulated immunity characterized by inflammation and injury of targeted tissues that have until recently been considered disparate disease processes. However, recent findings have implicated mast cells, in coordination with granulocytes and other immune effector cells, in the pathology of these two disorders. The BioBreeding (BB) DRlyp/lyp rat develops an autoimmune insulin-dependent diabetes similar to human type 1 diabetes mellitus (T1DM), whereas the BBDR+/+ rat does not. To better understand immune processes during development of T1DM, gene expression profiling at day (d) 40 (before insulitis) and d65 (before disease onset) was conducted on pancreatic lymph nodes of DRlyp/lyp, DR+/+, and Wistar-Furth (WF) rats. The eosinophil-recruiting chemokine, eotaxin, and the high-affinity IgE receptor (FcepsilonRI) were up-regulated >5-fold in d65 DRlyp/lyp vs d65 DR+/+ pancreatic lymph nodes by microarray (p < 0.05) and quantitative RT-PCR stud
Original languageEnglish
Pages (from-to)6993-7002
JournalJournal of Immunology
Volume173
Issue number11
Publication statusPublished - 2004
Externally publishedYes

Subject classification (UKÄ)

  • Immunology in the medical area

Fingerprint

Dive into the research topics of 'Involvement of eotaxin, eosinophils, and pancreatic predisposition in development of type 1 diabetes mellitus in the BioBreeding rat.'. Together they form a unique fingerprint.

Cite this