Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s

Pierre Montay-Gruel; Kristoffer Petersson; Maud Jaccard; Gaël Boivin; Jean François Germond; Benoit Petit; Raphaël Doenlen; Vincent Favaudon; François Bochud; Claude Bailat; Jean Bourhis; Marie Catherine Vozenin

doi:10.1016/j.radonc.2017.05.003

Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s

Pierre Montay-Gruel, Kristoffer Petersson, Maud Jaccard, Gaël Boivin, Jean François Germond, Benoit Petit, Raphaël Doenlen, Vincent Favaudon, François Bochud, Claude Bailat, Jean Bourhis, Marie Catherine Vozenin

Lausanne University Hospital

Research output: Contribution to journal › Article › peer-review

Abstract

This study shows for the first time that normal brain tissue toxicities after WBI can be reduced with increased dose rate. Spatial memory is preserved after WBI with mean dose rates above 100 Gy/s, whereas 10 Gy WBI at a conventional radiotherapy dose rate (0.1 Gy/s) totally impairs spatial memory.

Original language	English
Pages (from-to)	365-369
Journal	Radiotherapy and Oncology
Volume	124
Issue number	3
DOIs	https://doi.org/10.1016/j.radonc.2017.05.003
Publication status	Published - 2017
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2017 Elsevier B.V.

Free keywords

Cognition's preservation
Flash-RT
Whole brain irradiation

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10.1016/j.radonc.2017.05.003

Cite this

Montay-Gruel, P., Petersson, K., Jaccard, M., Boivin, G., Germond, J. F., Petit, B., Doenlen, R., Favaudon, V., Bochud, F., Bailat, C., Bourhis, J., & Vozenin, M. C. (2017). Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s. Radiotherapy and Oncology, 124(3), 365-369. https://doi.org/10.1016/j.radonc.2017.05.003

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abstract = "This study shows for the first time that normal brain tissue toxicities after WBI can be reduced with increased dose rate. Spatial memory is preserved after WBI with mean dose rates above 100 Gy/s, whereas 10 Gy WBI at a conventional radiotherapy dose rate (0.1 Gy/s) totally impairs spatial memory.",

keywords = "Cognition's preservation, Flash-RT, Whole brain irradiation",

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year = "2017",

doi = "10.1016/j.radonc.2017.05.003",

language = "English",

volume = "124",

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Montay-Gruel, P, Petersson, K, Jaccard, M, Boivin, G, Germond, JF, Petit, B, Doenlen, R, Favaudon, V, Bochud, F, Bailat, C, Bourhis, J & Vozenin, MC 2017, 'Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s', Radiotherapy and Oncology, vol. 124, no. 3, pp. 365-369. https://doi.org/10.1016/j.radonc.2017.05.003

TY - JOUR

T1 - Irradiation in a flash

T2 - Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s

AU - Montay-Gruel, Pierre

AU - Petersson, Kristoffer

AU - Jaccard, Maud

AU - Boivin, Gaël

AU - Germond, Jean François

AU - Petit, Benoit

AU - Doenlen, Raphaël

AU - Favaudon, Vincent

AU - Bochud, François

AU - Bailat, Claude

AU - Bourhis, Jean

AU - Vozenin, Marie Catherine

PY - 2017

Y1 - 2017

N2 - This study shows for the first time that normal brain tissue toxicities after WBI can be reduced with increased dose rate. Spatial memory is preserved after WBI with mean dose rates above 100 Gy/s, whereas 10 Gy WBI at a conventional radiotherapy dose rate (0.1 Gy/s) totally impairs spatial memory.

AB - This study shows for the first time that normal brain tissue toxicities after WBI can be reduced with increased dose rate. Spatial memory is preserved after WBI with mean dose rates above 100 Gy/s, whereas 10 Gy WBI at a conventional radiotherapy dose rate (0.1 Gy/s) totally impairs spatial memory.

KW - Cognition's preservation

KW - Flash-RT

KW - Whole brain irradiation

UR - http://www.scopus.com/inward/record.url?scp=85019639866&partnerID=8YFLogxK

U2 - 10.1016/j.radonc.2017.05.003

DO - 10.1016/j.radonc.2017.05.003

M3 - Article

C2 - 28545957

AN - SCOPUS:85019639866

SN - 0167-8140

VL - 124

SP - 365

EP - 369

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

IS - 3

ER -

Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s

Abstract

Bibliographical note

Free keywords

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