TY - JOUR
T1 - J-curve association between alcohol intake and varicose veins in Japan
T2 - The Shimane CoHRE Study
AU - Kohno, Kunie
AU - Niihara, Hiroyuki
AU - Hamano, Tsuyoshi
AU - Takeda, Miwako
AU - Nakagawa, Yusei
AU - Shiwaku, Kuninori
AU - Nabika, Toru
AU - Zöller, Bengt
AU - Li, Xinjun
AU - Sundquist, Kristina
AU - Sundquist, Jan
AU - Morita, Eishin
N1 - © 2019 Japanese Dermatological Association.
PY - 2019
Y1 - 2019
N2 - The effect of alcohol intake on varicose veins (VV) has not been determined by its consumption level. The aim of this study was to investigate the association between alcohol intake and VV in an elderly general population. Using a cross-sectional approach, the Shimane CoHRE Study data, comprising a total of 1060 participants, were analyzed. By multivariate regression analysis adjusted with basic characteristics, past work history, lifestyle-related factors and medical history, compared with non-drinkers, mild drinkers (<20.0 g/day) showed a significantly lower adjusted odds ratio (aOR) of VV (aOR = 0.64, P = 0.036). In a similar way, regular drinkers (1-5 days/week) showed a significantly lower aOR of VV when compared with occasional drinkers (aOR = 0.57, P = 0.032). VV and alcohol intake showed J-curve relationships. In a stratified analysis by alcohol consumption levels, the association of smoking and VV were also observed in moderate to heavy drinkers and habitual drinkers. These findings can provide better understanding of pathophysiological mechanism and be used for evidence-based patient education.
AB - The effect of alcohol intake on varicose veins (VV) has not been determined by its consumption level. The aim of this study was to investigate the association between alcohol intake and VV in an elderly general population. Using a cross-sectional approach, the Shimane CoHRE Study data, comprising a total of 1060 participants, were analyzed. By multivariate regression analysis adjusted with basic characteristics, past work history, lifestyle-related factors and medical history, compared with non-drinkers, mild drinkers (<20.0 g/day) showed a significantly lower adjusted odds ratio (aOR) of VV (aOR = 0.64, P = 0.036). In a similar way, regular drinkers (1-5 days/week) showed a significantly lower aOR of VV when compared with occasional drinkers (aOR = 0.57, P = 0.032). VV and alcohol intake showed J-curve relationships. In a stratified analysis by alcohol consumption levels, the association of smoking and VV were also observed in moderate to heavy drinkers and habitual drinkers. These findings can provide better understanding of pathophysiological mechanism and be used for evidence-based patient education.
UR - https://www.scopus.com/pages/publications/85070475442
U2 - 10.1111/1346-8138.15022
DO - 10.1111/1346-8138.15022
M3 - Article
C2 - 31353631
SN - 1346-8138
VL - 46
SP - 902
EP - 906
JO - Journal of Dermatology
JF - Journal of Dermatology
IS - 10
ER -