K-ATP-channels and glucagon secretion glucose-regulated

Patrik Rorsman, S Albert Salehi, Fernando Abdulkader, Matthias Braun, Patrick E. MacDonald

    Research output: Contribution to journalReview articlepeer-review

    75 Citations (Scopus)

    Abstract

    Glucagon, secreted by the a-cells of the pancreatic islets, is the most important glucose-increasing hormone of the body. The precise regulation of glucagon release remains incompletely defined but has been proposed to involve release of inhibitory factors from neighbouring P-cells (paracrine control). However, the observation that glucose can regulate glucagon secretion under conditions when insulin secretion does not occur argues that the a-cell is also equipped with its own intrinsic (exerted within the a-cell itself) glucose sensing. Here we consider the possible mechanisms involved with a focus on ATP-regulated K+-channels and changes in a-cell membrane potential.
    Original languageEnglish
    Pages (from-to)277-284
    JournalTrends in Endocrinology and Metabolism
    Volume19
    Issue number8
    DOIs
    Publication statusPublished - 2008

    Subject classification (UKÄ)

    • Endocrinology and Diabetes

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