Kinetic preference for interaction of cisplatin with the G-C-rich wobble basepair region in both tRNA(Ala) and Mh(Ala)

Pal Papsai; Jasmin Aldag; Tina Persson; Sofi Elmroth

doi:10.1039/b603833f

Kinetic preference for interaction of cisplatin with the G-C-rich wobble basepair region in both tRNA(Ala) and Mh(Ala)

Pal Papsai, Jasmin Aldag, Tina Persson, Sofi Elmroth

Research output: Contribution to journal › Article › peer-review

Abstract

The anticancer active complex cisplatin interacts preferentially with the common, G - C rich, wobble base pair region of both tRNA(Ala) and Mh(Ala) in a reaction that at pH 6.3 is rate limited by the acid hydrolysis of the metal complex.

Original language	English
Pages (from-to)	3515-3517
Journal	Dalton Transactions
Issue number	29
DOIs	https://doi.org/10.1039/b603833f
Publication status	Published - 2006

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Biological Sciences

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10.1039/b603833f

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title = "Kinetic preference for interaction of cisplatin with the G-C-rich wobble basepair region in both tRNA(Ala) and Mh(Ala)",

abstract = "The anticancer active complex cisplatin interacts preferentially with the common, G - C rich, wobble base pair region of both tRNA(Ala) and Mh(Ala) in a reaction that at pH 6.3 is rate limited by the acid hydrolysis of the metal complex.",

author = "Pal Papsai and Jasmin Aldag and Tina Persson and Sofi Elmroth",

year = "2006",

doi = "10.1039/b603833f",

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journal = "Dalton Transactions",

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publisher = "Royal Society of Chemistry",

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AU - Papsai, Pal

AU - Aldag, Jasmin

AU - Persson, Tina

AU - Elmroth, Sofi

PY - 2006

Y1 - 2006

N2 - The anticancer active complex cisplatin interacts preferentially with the common, G - C rich, wobble base pair region of both tRNA(Ala) and Mh(Ala) in a reaction that at pH 6.3 is rate limited by the acid hydrolysis of the metal complex.

AB - The anticancer active complex cisplatin interacts preferentially with the common, G - C rich, wobble base pair region of both tRNA(Ala) and Mh(Ala) in a reaction that at pH 6.3 is rate limited by the acid hydrolysis of the metal complex.

UR - https://www.scopus.com/pages/publications/33746191455

U2 - 10.1039/b603833f

DO - 10.1039/b603833f

M3 - Article

C2 - 16855751

SN - 1477-9234

SP - 3515

EP - 3517

JO - Dalton Transactions

JF - Dalton Transactions

IS - 29

ER -

Kinetic preference for interaction of cisplatin with the G-C-rich wobble basepair region in both tRNA(Ala) and Mh(Ala)

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