Label-free and non-contact platelet analysis platform

E Persson, Carl Johannesson, David Erlinge, Mikael Evander

Research output: Chapter in Book/Report/Conference proceedingPaper in conference proceedingpeer-review

Abstract

We present a non-contact platelet functional analysis platform based on acoustic trapping of platelet clusters and activation monitoring using impedance spectroscopy. The system was characterized using polystyrene particles and human platelets. The system was also capable of transferring platelets from plasma into a controlled buffer. Trapped platelets were activated using 20 and 40 μM TRAP and their responses were recorded with impedance spectroscopy. The system shows great promise as a miniaturized, automatable platform for platelet analysis.

Original languageEnglish
Title of host publication18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
PublisherChemical and Biological Microsystems Society
Pages2542-2543
Number of pages2
ISBN (Print)9780979806476
Publication statusPublished - 2014
Event18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States
Duration: 2014 Oct 262014 Oct 30
Conference number: 18

Conference

Conference18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
Country/TerritoryUnited States
CitySan Antonio
Period2014/10/262014/10/30

Subject classification (UKÄ)

  • Medicinal Chemistry

Keywords

  • Acoustic trapping
  • Impedance spectroscopy
  • Platelet functional analysis

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