Lack of association between genetic variations in the KALRN region and ischemic stroke

Sandra Olsson, Katarina Jood, Olle Melander, Marketa Sjögren, Bo Norrving, Michael Nilsson, Arne Lindgren, Christina Jern

Research output: Contribution to journalArticlepeer-review

8 Citations (SciVal)

Abstract

Objectives: To investigate whether KALRN gene variation is associated with ischemic stroke (IS). Design and methods: Associations to overall IS and IS subtypes were investigated in SAHLSIS, which comprises 844 patients with IS and 668 controls. Results: Associations between KALRN SNPs and overall IS and cardioembolic stroke were detected. Associations for overall IS were investigated in two additional Swedish samples, but could not be replicated. Conclusion: KALRN gene variation is not associated with overall IS. (C) 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
Original languageEnglish
Pages (from-to)1018-1020
JournalClinical Biochemistry
Volume44
Issue number12
DOIs
Publication statusPublished - 2011

Subject classification (UKÄ)

  • Biochemistry and Molecular Biology

Keywords

  • Single nucleotide polymorphism
  • Genetics
  • Ischemic stroke
  • Kalirin
  • RhoGEF

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