Lactobacillus acidophilus autolysins inhibit Helicobacter pylori in vitro

Graciela L. Lorca; Torkel Wadström; Graciela Font de Valdez; Åsa Ljungh

doi:10.1007/s002840010175

Lactobacillus acidophilus autolysins inhibit Helicobacter pylori in vitro

Graciela L. Lorca, Torkel Wadström, Graciela Font de Valdez, Åsa Ljungh

Division of Medical Microbiology

Research output: Contribution to journal › Article › peer-review

Abstract

Antibacterial activity of 17 strains of lactobacilli was tested against 10 strains of H. pylori. The inhibition observed was related to the acid production and the low pH attained. No relationship between CagA phenotype of H, pylori strains and tolerance to lactic acid was observed. In mixed cultures, L. acidophilus CRL 639 showed an autolytic behavior after 24 h of culture. At this moment, H. py[ori CCUG17874 showed a decrease of 2 log-cycle, and no viable count was detected after 48 h, The bactericidal effect of L. acidophilus CRL 639 in mixed cultures is related to a proteinaceous compound released after cell lysis.

Original language	English
Pages (from-to)	39-44
Journal	Current Microbiology
Volume	42
Issue number	1
DOIs	https://doi.org/10.1007/s002840010175
Publication status	Published - 2001

Subject classification (UKÄ)

Microbiology in the medical area

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10.1007/s002840010175

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title = "Lactobacillus acidophilus autolysins inhibit Helicobacter pylori in vitro",

abstract = "Antibacterial activity of 17 strains of lactobacilli was tested against 10 strains of H. pylori. The inhibition observed was related to the acid production and the low pH attained. No relationship between CagA phenotype of H, pylori strains and tolerance to lactic acid was observed. In mixed cultures, L. acidophilus CRL 639 showed an autolytic behavior after 24 h of culture. At this moment, H. py[ori CCUG17874 showed a decrease of 2 log-cycle, and no viable count was detected after 48 h, The bactericidal effect of L. acidophilus CRL 639 in mixed cultures is related to a proteinaceous compound released after cell lysis.",

author = "Lorca, {Graciela L.} and Torkel Wadstr{\"o}m and {Font de Valdez}, Graciela and {\AA}sa Ljungh",

year = "2001",

doi = "10.1007/s002840010175",

language = "English",

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pages = "39--44",

journal = "Current Microbiology",

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T1 - Lactobacillus acidophilus autolysins inhibit Helicobacter pylori in vitro

AU - Lorca, Graciela L.

AU - Wadström, Torkel

AU - Font de Valdez, Graciela

AU - Ljungh, Åsa

PY - 2001

Y1 - 2001

N2 - Antibacterial activity of 17 strains of lactobacilli was tested against 10 strains of H. pylori. The inhibition observed was related to the acid production and the low pH attained. No relationship between CagA phenotype of H, pylori strains and tolerance to lactic acid was observed. In mixed cultures, L. acidophilus CRL 639 showed an autolytic behavior after 24 h of culture. At this moment, H. py[ori CCUG17874 showed a decrease of 2 log-cycle, and no viable count was detected after 48 h, The bactericidal effect of L. acidophilus CRL 639 in mixed cultures is related to a proteinaceous compound released after cell lysis.

AB - Antibacterial activity of 17 strains of lactobacilli was tested against 10 strains of H. pylori. The inhibition observed was related to the acid production and the low pH attained. No relationship between CagA phenotype of H, pylori strains and tolerance to lactic acid was observed. In mixed cultures, L. acidophilus CRL 639 showed an autolytic behavior after 24 h of culture. At this moment, H. py[ori CCUG17874 showed a decrease of 2 log-cycle, and no viable count was detected after 48 h, The bactericidal effect of L. acidophilus CRL 639 in mixed cultures is related to a proteinaceous compound released after cell lysis.

U2 - 10.1007/s002840010175

DO - 10.1007/s002840010175

M3 - Article

SN - 0343-8651

VL - 42

SP - 39

EP - 44

JO - Current Microbiology

JF - Current Microbiology

IS - 1

ER -

Lactobacillus acidophilus autolysins inhibit Helicobacter pylori in vitro

Abstract

Subject classification (UKÄ)

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