@inbook{293bbeaf08bc49b5b338eeadb345afec,
title = "Leukotriene D4-induced calcium signaling in human intestinal epithelial cells",
abstract = "LTD4 induces a calcium signal that consists of a mobilization from internal stores regulated by PTX-insensitive G protein, Rho, and, an influx across the plasma membrane regulated by PTX-sensitive Gi protein in human intestinal epithelial cells. The LTD4 induced mobilization of Ca2+ is mediated by a PH domain dependent association between PLC-gamma 1 and G beta gamma subunits. This interaction requires Src kinase activity as well as the association of this kinase with PLC-gamma 1, suggesting a G beta gamma mediated recruitment of proteins to the plasma membrane and formation of a signaling complex which is essential for the downstream Ca2+ signal. We found a cAMP-dependent protein kinase activity upstream of tyrosine kinase(s) and downstream of Gi protein, that is essential for LTD4-induced Ca2+ influx. This model of the LTD4-induced Ca2+ signaling pathways in intestinal epithelial cells is outlined schematically in Fig. 1.",
keywords = "Calcium Signaling/drug effects, Humans, Intestinal Mucosa/drug effects, Leukotriene D4/pharmacology",
author = "Thodeti, \{Charles Kumar\} and Anita Sj{\"o}lander",
year = "2002",
doi = "10.1007/978-1-4615-0193-0\_29",
language = "English",
volume = "507",
series = "Advances in Experimental Medicine and Biology",
publisher = "Springer",
pages = "187--91",
editor = "K Honn and L Marnett and S Nigam and E Dennis and C Serhan",
booktitle = "Eicosanoids and other bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5",
address = "Germany",
}