Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation.

Jia-Yi Li; Elisabet Englund; Janice L Holton; Denis Soulet; Peter Hagell; Andrew J Lees; Tammaryn Lashley; Niall P Quinn; Stig Rehncrona; Anders Björklund; Håkan Widner; Tamas Revesz; Olle Lindvall; Patrik Brundin

doi:10.1038/nm1746

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation.

Jia-Yi Li, Elisabet Englund, Janice L Holton, Denis Soulet, Peter Hagell, Andrew J Lees, Tammaryn Lashley, Niall P Quinn, Stig Rehncrona, Anders Björklund, Håkan Widner, Tamas Revesz, Olle Lindvall, Patrik Brundin

Research output: Contribution to journal › Article › peer-review

Abstract

Two subjects with Parkinson's disease who had long-term survival of transplanted fetal mesencephalic dopaminergic neurons (11-16 years) developed alpha-synuclein-positive Lewy bodies in grafted neurons. Our observation has key implications for understanding Parkinson's pathogenesis by providing the first evidence, to our knowledge, that the disease can propagate from host to graft cells. However, available data suggest that the majority of grafted cells are functionally unimpaired after a decade, and recipients can still experience long-term symptomatic relief.

Original language	English
Pages (from-to)	501-503
Journal	Nature Medicine
Volume	14
DOIs	https://doi.org/10.1038/nm1746
Publication status	Published - 2008

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Neuronal Survival (013212041), Neurobiology (013212024), Pathology, (Lund) (013030000), Neurology, Lund (013027000), Neurosurgery (013026000), Neural Plasticity and Repair (013210080), Caring Sciences (Closed 2012) (016514020)

Subject classification (UKÄ)

Neurosciences
Neurology

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10.1038/nm1746

http://www.ncbi.nlm.nih.gov/pubmed/18391963?dopt=Abstract

Cite this

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title = "Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation.",

abstract = "Two subjects with Parkinson's disease who had long-term survival of transplanted fetal mesencephalic dopaminergic neurons (11-16 years) developed alpha-synuclein-positive Lewy bodies in grafted neurons. Our observation has key implications for understanding Parkinson's pathogenesis by providing the first evidence, to our knowledge, that the disease can propagate from host to graft cells. However, available data suggest that the majority of grafted cells are functionally unimpaired after a decade, and recipients can still experience long-term symptomatic relief.",

author = "Jia-Yi Li and Elisabet Englund and Holton, {Janice L} and Denis Soulet and Peter Hagell and Lees, {Andrew J} and Tammaryn Lashley and Quinn, {Niall P} and Stig Rehncrona and Anders Bj{\"o}rklund and H{\aa}kan Widner and Tamas Revesz and Olle Lindvall and Patrik Brundin",

note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041), Neurobiology (013212024), Pathology, (Lund) (013030000), Neurology, Lund (013027000), Neurosurgery (013026000), Neural Plasticity and Repair (013210080), Caring Sciences (Closed 2012) (016514020)",

year = "2008",

doi = "10.1038/nm1746",

language = "English",

volume = "14",

pages = "501--503",

journal = "Nature Medicine",

issn = "1546-170X",

publisher = "Nature Publishing Group",

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TY - JOUR

T1 - Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation.

AU - Li, Jia-Yi

AU - Englund, Elisabet

AU - Holton, Janice L

AU - Soulet, Denis

AU - Hagell, Peter

AU - Lees, Andrew J

AU - Lashley, Tammaryn

AU - Quinn, Niall P

AU - Rehncrona, Stig

AU - Björklund, Anders

AU - Widner, Håkan

AU - Revesz, Tamas

AU - Lindvall, Olle

AU - Brundin, Patrik

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041), Neurobiology (013212024), Pathology, (Lund) (013030000), Neurology, Lund (013027000), Neurosurgery (013026000), Neural Plasticity and Repair (013210080), Caring Sciences (Closed 2012) (016514020)

PY - 2008

Y1 - 2008

N2 - Two subjects with Parkinson's disease who had long-term survival of transplanted fetal mesencephalic dopaminergic neurons (11-16 years) developed alpha-synuclein-positive Lewy bodies in grafted neurons. Our observation has key implications for understanding Parkinson's pathogenesis by providing the first evidence, to our knowledge, that the disease can propagate from host to graft cells. However, available data suggest that the majority of grafted cells are functionally unimpaired after a decade, and recipients can still experience long-term symptomatic relief.

AB - Two subjects with Parkinson's disease who had long-term survival of transplanted fetal mesencephalic dopaminergic neurons (11-16 years) developed alpha-synuclein-positive Lewy bodies in grafted neurons. Our observation has key implications for understanding Parkinson's pathogenesis by providing the first evidence, to our knowledge, that the disease can propagate from host to graft cells. However, available data suggest that the majority of grafted cells are functionally unimpaired after a decade, and recipients can still experience long-term symptomatic relief.

U2 - 10.1038/nm1746

DO - 10.1038/nm1746

M3 - Article

SN - 1546-170X

VL - 14

SP - 501

EP - 503

JO - Nature Medicine

JF - Nature Medicine

ER -

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation.

Abstract

Bibliographical note

Subject classification (UKÄ)

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