Projects per year
Abstract
The lack of methods to evaluate mechanical function of donated hearts in the context of transplantation imposes large precautionary margins, translating into a low utilization rate of donor organs. This has spawned research into cyber-physical models constituting artificial afterloads (arterial trees), that can serve to evaluate the contractile capacity of the donor heart. The Windkessel model is an established linear time-invariant afterload model, that researchers committed to creating a cyber-physical afterload have used as a template. With aortic volumetric flow as input and aortic pressure as output, it is not directly obvious how a Windkessel model will respond to changes in heart contractility. We transform the classic Windkessel model to relate power, rather than flow, to pressure. This alters the model into a differential-algebraic equation, albeit one that is straightforward to simulate. We then propose a power signal model, that is based on pressure and flow measurements and optimal in a Bayesian sense within the class of C2 signals. Finally, we show how the proposed signal model can be used to create relevant simulation scenarios, and use this to illustrate why it is problematic to use the Windkessel model as a basis for designing a clinically relevant artificial afterload.
Original language | English |
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Title of host publication | American Control Conference |
Pages | 2994-2999 |
Volume | 2022 |
DOIs | |
Publication status | Published - 2022 |
Event | American Control Conference, 2022 - Atlanta, GA, United States Duration: 2022 Jun 8 → 2022 Jun 10 https://acc2022.a2c2.org/ |
Conference
Conference | American Control Conference, 2022 |
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Abbreviated title | ACC |
Country/Territory | United States |
City | GA |
Period | 2022/06/08 → 2022/06/10 |
Internet address |
Subject classification (UKÄ)
- Control Engineering
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Dive into the research topics of 'Limitations of time-delayed case isolation in heterogeneous SIR models'. Together they form a unique fingerprint.Projects
- 1 Finished
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COVID-19: Dynamical modelling for estimation and prediction
Bernhardsson, B. (Researcher), Eker, J. (Researcher), Govaert, A. (Researcher), Gustafsson, F. (Researcher), Hansson, J. (Researcher), Heimerson, A. (Researcher), Jaldén, J. (Researcher), Jidling, C. (Researcher), Jöud, A. (Researcher), Pates, R. (Researcher), B. Schön, T. (Researcher), Soltesz, K. (Researcher), Spreco, A. (Researcher), Tegling, E. (Researcher), Timpka, T. (Researcher), Wacker, A. (Researcher), Hendeby, G. (Researcher) & Rath, A. (Research student)
2020/01/01 → 2022/12/31
Project: Research