Limited impact of fibromodulin deficiency on the development of experimental skin fibrosis

Kristofer Andréasson; Renata Gustafsson; Kristina Rydell-Törmänen; Gunilla Westergren-Thorsson; Tore Saxne; Roger Hesselstrand

doi:10.1111/exd.13012

Limited impact of fibromodulin deficiency on the development of experimental skin fibrosis

Kristofer Andréasson, Renata Gustafsson, Kristina Rydell-Törmänen, Gunilla Westergren-Thorsson, Tore Saxne, Roger Hesselstrand

Research output: Contribution to journal › Article › peer-review

Abstract

Excessive production of collagen is the hallmark of fatal diseases of fibrosis such as systemic sclerosis. Overexpression of the proteoglycan fibromodulin (FMOD) has been associated with improved wound healing and scarless repair. In this study we have investigated the consequences of FMOD deficiency on the development of experimental skin fibrosis. Using immunohistochemistry, we identified FMOD in both human and murine fibrotic skin. In the bleomycin model of skin fibrosis, FMOD(-/-) mice developed skin fibrosis to a similar degree compared to FMOD(+/+) mice. Analysis of skin ultrastructure using transmission electron microscopy revealed a significant reduction in collagen fibril diameter in FMOD(-/-) but not FMOD(+/+) mice following fibrosis. We conclude that impact of FMOD deficiency on the development of experimental skin fibrosis is limited. This article is protected by copyright. All rights reserved.

Original language	English
Journal	Experimental Dermatology
DOIs	https://doi.org/10.1111/exd.13012
Publication status	Published - 2016 Mar 21

Subject classification (UKÄ)

Dermatology and Venereal Diseases

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10.1111/exd.13012

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title = "Limited impact of fibromodulin deficiency on the development of experimental skin fibrosis",

abstract = "Excessive production of collagen is the hallmark of fatal diseases of fibrosis such as systemic sclerosis. Overexpression of the proteoglycan fibromodulin (FMOD) has been associated with improved wound healing and scarless repair. In this study we have investigated the consequences of FMOD deficiency on the development of experimental skin fibrosis. Using immunohistochemistry, we identified FMOD in both human and murine fibrotic skin. In the bleomycin model of skin fibrosis, FMOD(-/-) mice developed skin fibrosis to a similar degree compared to FMOD(+/+) mice. Analysis of skin ultrastructure using transmission electron microscopy revealed a significant reduction in collagen fibril diameter in FMOD(-/-) but not FMOD(+/+) mice following fibrosis. We conclude that impact of FMOD deficiency on the development of experimental skin fibrosis is limited. This article is protected by copyright. All rights reserved.",

author = "Kristofer Andr{\'e}asson and Renata Gustafsson and Kristina Rydell-T{\"o}rm{\"a}nen and Gunilla Westergren-Thorsson and Tore Saxne and Roger Hesselstrand",

year = "2016",

month = mar,

day = "21",

doi = "10.1111/exd.13012",

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journal = "Experimental Dermatology",

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TY - JOUR

T1 - Limited impact of fibromodulin deficiency on the development of experimental skin fibrosis

AU - Andréasson, Kristofer

AU - Gustafsson, Renata

AU - Rydell-Törmänen, Kristina

AU - Westergren-Thorsson, Gunilla

AU - Saxne, Tore

AU - Hesselstrand, Roger

PY - 2016/3/21

Y1 - 2016/3/21

N2 - Excessive production of collagen is the hallmark of fatal diseases of fibrosis such as systemic sclerosis. Overexpression of the proteoglycan fibromodulin (FMOD) has been associated with improved wound healing and scarless repair. In this study we have investigated the consequences of FMOD deficiency on the development of experimental skin fibrosis. Using immunohistochemistry, we identified FMOD in both human and murine fibrotic skin. In the bleomycin model of skin fibrosis, FMOD(-/-) mice developed skin fibrosis to a similar degree compared to FMOD(+/+) mice. Analysis of skin ultrastructure using transmission electron microscopy revealed a significant reduction in collagen fibril diameter in FMOD(-/-) but not FMOD(+/+) mice following fibrosis. We conclude that impact of FMOD deficiency on the development of experimental skin fibrosis is limited. This article is protected by copyright. All rights reserved.

AB - Excessive production of collagen is the hallmark of fatal diseases of fibrosis such as systemic sclerosis. Overexpression of the proteoglycan fibromodulin (FMOD) has been associated with improved wound healing and scarless repair. In this study we have investigated the consequences of FMOD deficiency on the development of experimental skin fibrosis. Using immunohistochemistry, we identified FMOD in both human and murine fibrotic skin. In the bleomycin model of skin fibrosis, FMOD(-/-) mice developed skin fibrosis to a similar degree compared to FMOD(+/+) mice. Analysis of skin ultrastructure using transmission electron microscopy revealed a significant reduction in collagen fibril diameter in FMOD(-/-) but not FMOD(+/+) mice following fibrosis. We conclude that impact of FMOD deficiency on the development of experimental skin fibrosis is limited. This article is protected by copyright. All rights reserved.

U2 - 10.1111/exd.13012

DO - 10.1111/exd.13012

M3 - Article

C2 - 26997256

SN - 0906-6705

JO - Experimental Dermatology

JF - Experimental Dermatology

ER -

Limited impact of fibromodulin deficiency on the development of experimental skin fibrosis

Abstract

Subject classification (UKÄ)

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