Linking EORTC QLQ-C-30 and PedsQL/PEDQOL physical functioning scores in patients with osteosarcoma

Axel Budde, Katja Baust, Leonie Weinhold, Mark Bernstein, Stefan Bielack, Catharina Dhooge, Lars Hjorth, Katherine A. Janeway, Meriel Jenney, Mark D. Krailo, Neyssa Marina, Rajaram Nagarajan, Sigbjørn Smeland, Matthew R. Sydes, Patricia De Vos, Jeremy Whelan, Andreas Wiener, Gabriele Calaminus, Matthias Schmid

Research output: Contribution to journalArticlepeer-review


Purpose: The available questionnaires for quality-of-life (QoL) assessments are age-group specific, limiting comparability and impeding longitudinal analyses. The comparability of measurements, however, is a necessary condition for gaining scientific evidence. To overcome this problem, we assessed the viability of harmonising data from paediatric and adult patient-reported outcome (PRO) measures. Method: To this end, we linked physical functioning scores from the Paediatric Quality of Life Inventory (PedsQL) and the Paediatric Quality of Life Questionnaire (PEDQOL) to the European Organisation for Research and Treatment of Cancer Core Questionnaire (EORTC QLQ-C30) for adults. Samples from the EURAMOS-1 QoL sub-study of 75 (PedsQL) and 112 (PEDQOL) adolescent osteosarcoma patients were concurrently administered both paediatric and adult questionnaires on 98 (PedsQL) and 156 (PEDQOL) occasions. We identified corresponding scores using the single-group equipercentile linking method. Results: Linked physical functioning scores showed sufficient concordance to the EORTC QLQ-C30: Lin's ρ = 0.74 (PedsQL) and Lin's ρ = 0.64 (PEDQOL). Conclusion: Score linking provides clinicians and researchers with a common metric for assessing QoL with PRO measures across the entire lifespan of patients.

Original languageEnglish
Pages (from-to)209-235
Number of pages27
JournalEuropean Journal of Cancer
Publication statusPublished - 2022 Jul

Subject classification (UKÄ)

  • Other Medical Sciences not elsewhere specified


  • Childhood cancer
  • Paediatric quality of life inventory (PedsQL)
  • Paediatric quality of life questionnaire (PEDQOL)
  • Patient-reported outcome (PRO)
  • Physical functioning quality-of-life (QoL)
  • Score linking


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