Lipopolysaccharide (LPS) inhalation in healthy subjects causes bronchoalveolar neutrophilia, lymphocytosis, and fibronectin increase

Thomas Sandstrom; Leif Bjermer; Ragnar Rylander

doi:10.1002/ajim.4700250127

Lipopolysaccharide (LPS) inhalation in healthy subjects causes bronchoalveolar neutrophilia, lymphocytosis, and fibronectin increase

Thomas Sandstrom, Leif Bjermer, Ragnar Rylander

External Organization - Unknown

Research output: Contribution to journal › Article › peer-review

Abstract

Eight healthy volunteers were exposed to purified lipopolysaccharide (LPS) by controlled inhalation. Bronchoalveolar lavage (BAL) 3 hours after exposure revealed a pronounced neutrophilia, increase in lymphocytes, fibronectin concentration, and decrease in alveolar macrophage phagocytosis, as compared to a reference BAL.

Original language	English
Pages (from-to)	103-104
Journal	American Journal of Industrial Medicine
Volume	25
Issue number	1
DOIs	https://doi.org/10.1002/ajim.4700250127
Publication status	Published - 1994
Externally published	Yes

Subject classification (UKÄ)

Respiratory Medicine and Allergy

Free keywords

organic dusts
inflammation
endotoxins
BAL
inhalational exposures

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10.1002/ajim.4700250127

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@article{0f41cef3c3494207abc57c5a8aaad292,

title = "Lipopolysaccharide (LPS) inhalation in healthy subjects causes bronchoalveolar neutrophilia, lymphocytosis, and fibronectin increase",

abstract = "Eight healthy volunteers were exposed to purified lipopolysaccharide (LPS) by controlled inhalation. Bronchoalveolar lavage (BAL) 3 hours after exposure revealed a pronounced neutrophilia, increase in lymphocytes, fibronectin concentration, and decrease in alveolar macrophage phagocytosis, as compared to a reference BAL.",

keywords = "organic dusts, inflammation, endotoxins, BAL, inhalational exposures",

author = "Thomas Sandstrom and Leif Bjermer and Ragnar Rylander",

year = "1994",

doi = "10.1002/ajim.4700250127",

language = "English",

volume = "25",

pages = "103--104",

journal = "American Journal of Industrial Medicine",

issn = "0271-3586",

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number = "1",

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T1 - Lipopolysaccharide (LPS) inhalation in healthy subjects causes bronchoalveolar neutrophilia, lymphocytosis, and fibronectin increase

AU - Sandstrom, Thomas

AU - Bjermer, Leif

AU - Rylander, Ragnar

PY - 1994

Y1 - 1994

N2 - Eight healthy volunteers were exposed to purified lipopolysaccharide (LPS) by controlled inhalation. Bronchoalveolar lavage (BAL) 3 hours after exposure revealed a pronounced neutrophilia, increase in lymphocytes, fibronectin concentration, and decrease in alveolar macrophage phagocytosis, as compared to a reference BAL.

AB - Eight healthy volunteers were exposed to purified lipopolysaccharide (LPS) by controlled inhalation. Bronchoalveolar lavage (BAL) 3 hours after exposure revealed a pronounced neutrophilia, increase in lymphocytes, fibronectin concentration, and decrease in alveolar macrophage phagocytosis, as compared to a reference BAL.

KW - organic dusts

KW - inflammation

KW - endotoxins

KW - BAL

KW - inhalational exposures

U2 - 10.1002/ajim.4700250127

DO - 10.1002/ajim.4700250127

M3 - Article

SN - 0271-3586

VL - 25

SP - 103

EP - 104

JO - American Journal of Industrial Medicine

JF - American Journal of Industrial Medicine

IS - 1

ER -

Lipopolysaccharide (LPS) inhalation in healthy subjects causes bronchoalveolar neutrophilia, lymphocytosis, and fibronectin increase

Abstract

Subject classification (UKÄ)

Free keywords

Access to Document

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Cite this