TY - JOUR
T1 - Long-term exposure to transportation noise and ischemic heart disease
T2 - A pooled analysis of nine scandinavian cohorts
AU - Pyko, Andrei
AU - Roswall, Nina
AU - Ögren, Mikael
AU - Oudin, Anna
AU - Rosengren, Annika
AU - Eriksson, Charlotta
AU - Segersson, David
AU - Rizzuto, Debora
AU - Andersson, Eva M.
AU - Aasvang, Gunn Marit
AU - Engström, Gunnar
AU - Gudjonsdottir, Hrafnhildur
AU - Jørgensen, Jeanette T.
AU - Selander, Jenny
AU - Christensen, Jesper H.
AU - Brandt, Jørgen
AU - Leander, Karin
AU - Overvad, Kim
AU - Eneroth, Kristina
AU - Mattisson, Kristoffer
AU - Barregard, Lars
AU - Stockfelt, Leo
AU - Albin, Maria
AU - Simonsen, Mette K.
AU - Tiittanen, Pekka
AU - Molnar, Peter
AU - Ljungman, Petter
AU - Jensen, Steen Solvang
AU - Gustafsson, Susanna
AU - Lanki, Timo
AU - Lim, Youn Hee
AU - Andersen, Zorana J.
AU - Sørensen, Mette
AU - Pershagen, Göran
PY - 2023
Y1 - 2023
N2 - BACKGROUND: Transportation noise may induce cardiovascular disease, but the public health implications are unclear. OBJECTIVES: The study aimed to assess exposure-response relationships for different transportation noise sources and ischemic heart disease (IHD), including subtypes. METHODS: Pooled analyses were performed of nine cohorts from Denmark and Sweden, together including 132,801 subjects. Time-weighted long-term exposure to road, railway, and aircraft noise, as well as air pollution, was estimated based on residential histories. Hazard ratios (HRs) were cal-culated using Cox proportional hazards models following adjustment for lifestyle and socioeconomic risk factors. RESULTS: A total of 22,459 incident cases of IHD were identified during follow-up from national patient and mortality registers, including 7,682 cases of myocardial infarction. The adjusted HR for IHD was 1.03 [95% confidence interval (CI) 1.00, 1.05] per 10 dB Lden for both road and railway noise exposure during 5 y prior to the event. Higher risks were indicated for IHD excluding angina pectoris cases, with HRs of 1.06 (95% CI: 1.03, 1.08) and 1.05 (95% CI: 1.01, 1.08) per 10 dB Lden for road and railway noise, respectively. Corresponding HRs for myo-cardial infarction were 1.02 (95% CI: 0.99, 1.05) and 1.04 (95% CI: 0.99, 1.08). Increased risks were observed for aircraft noise but without clear exposure-response relations. A threshold at around 55 dB Lden was suggested in the exposure-response relation for road traffic noise and IHD. DISCUSSION: Exposure to road, railway, and aircraft noise in the prior 5 y was associated with an increased risk of IHD, particularly after exclusion of angina pectoris cases, which are less well identified in the registries.
AB - BACKGROUND: Transportation noise may induce cardiovascular disease, but the public health implications are unclear. OBJECTIVES: The study aimed to assess exposure-response relationships for different transportation noise sources and ischemic heart disease (IHD), including subtypes. METHODS: Pooled analyses were performed of nine cohorts from Denmark and Sweden, together including 132,801 subjects. Time-weighted long-term exposure to road, railway, and aircraft noise, as well as air pollution, was estimated based on residential histories. Hazard ratios (HRs) were cal-culated using Cox proportional hazards models following adjustment for lifestyle and socioeconomic risk factors. RESULTS: A total of 22,459 incident cases of IHD were identified during follow-up from national patient and mortality registers, including 7,682 cases of myocardial infarction. The adjusted HR for IHD was 1.03 [95% confidence interval (CI) 1.00, 1.05] per 10 dB Lden for both road and railway noise exposure during 5 y prior to the event. Higher risks were indicated for IHD excluding angina pectoris cases, with HRs of 1.06 (95% CI: 1.03, 1.08) and 1.05 (95% CI: 1.01, 1.08) per 10 dB Lden for road and railway noise, respectively. Corresponding HRs for myo-cardial infarction were 1.02 (95% CI: 0.99, 1.05) and 1.04 (95% CI: 0.99, 1.08). Increased risks were observed for aircraft noise but without clear exposure-response relations. A threshold at around 55 dB Lden was suggested in the exposure-response relation for road traffic noise and IHD. DISCUSSION: Exposure to road, railway, and aircraft noise in the prior 5 y was associated with an increased risk of IHD, particularly after exclusion of angina pectoris cases, which are less well identified in the registries.
U2 - 10.1289/EHP10745
DO - 10.1289/EHP10745
M3 - Article
C2 - 36607286
AN - SCOPUS:85145955612
SN - 0091-6765
VL - 131
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
IS - 1
M1 - 017003
ER -