Long-term exposure to transportation noise and ischemic heart disease: A pooled analysis of nine scandinavian cohorts

Andrei Pyko, Nina Roswall, Mikael Ögren, Anna Oudin, Annika Rosengren, Charlotta Eriksson, David Segersson, Debora Rizzuto, Eva M. Andersson, Gunn Marit Aasvang, Gunnar Engström, Hrafnhildur Gudjonsdottir, Jeanette T. Jørgensen, Jenny Selander, Jesper H. Christensen, Jørgen Brandt, Karin Leander, Kim Overvad, Kristina Eneroth, Kristoffer MattissonLars Barregard, Leo Stockfelt, Maria Albin, Mette K. Simonsen, Pekka Tiittanen, Peter Molnar, Petter Ljungman, Steen Solvang Jensen, Susanna Gustafsson, Timo Lanki, Youn Hee Lim, Zorana J. Andersen, Mette Sørensen, Göran Pershagen

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Transportation noise may induce cardiovascular disease, but the public health implications are unclear. OBJECTIVES: The study aimed to assess exposure-response relationships for different transportation noise sources and ischemic heart disease (IHD), including subtypes. METHODS: Pooled analyses were performed of nine cohorts from Denmark and Sweden, together including 132,801 subjects. Time-weighted long-term exposure to road, railway, and aircraft noise, as well as air pollution, was estimated based on residential histories. Hazard ratios (HRs) were cal-culated using Cox proportional hazards models following adjustment for lifestyle and socioeconomic risk factors. RESULTS: A total of 22,459 incident cases of IHD were identified during follow-up from national patient and mortality registers, including 7,682 cases of myocardial infarction. The adjusted HR for IHD was 1.03 [95% confidence interval (CI) 1.00, 1.05] per 10 dB Lden for both road and railway noise exposure during 5 y prior to the event. Higher risks were indicated for IHD excluding angina pectoris cases, with HRs of 1.06 (95% CI: 1.03, 1.08) and 1.05 (95% CI: 1.01, 1.08) per 10 dB Lden for road and railway noise, respectively. Corresponding HRs for myo-cardial infarction were 1.02 (95% CI: 0.99, 1.05) and 1.04 (95% CI: 0.99, 1.08). Increased risks were observed for aircraft noise but without clear exposure-response relations. A threshold at around 55 dB Lden was suggested in the exposure-response relation for road traffic noise and IHD. DISCUSSION: Exposure to road, railway, and aircraft noise in the prior 5 y was associated with an increased risk of IHD, particularly after exclusion of angina pectoris cases, which are less well identified in the registries.

Original languageEnglish
Article number017003
JournalEnvironmental Health Perspectives
Volume131
Issue number1
DOIs
Publication statusPublished - 2023

Subject classification (UKÄ)

  • Environmental Health and Occupational Health

Fingerprint

Dive into the research topics of 'Long-term exposure to transportation noise and ischemic heart disease: A pooled analysis of nine scandinavian cohorts'. Together they form a unique fingerprint.

Cite this