Long-term testosterone stimulation induces hyperplasia in the guinea-pig prostate.

Stefan Acosta; Nishtman Dizeyi; R Feinstein; Stefan Pierzynowski; Per-Anders Abrahamsson

doi:10.1038/sj.pcan.4500744

Long-term testosterone stimulation induces hyperplasia in the guinea-pig prostate.

Stefan Acosta, Nishtman Dizeyi, R Feinstein, Stefan Pierzynowski, Per-Anders Abrahamsson

Department of Clinical Sciences, Malmö

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Abstract

The relation between supraphysiologic circulating testosterone levels and prostatic diseases is unclear and difficult to study in men. Animal models may be advantageous. Based on a pilot study, testosterone enantate 50 mg (n=12) or 25 mg (n=12) was administered to guinea-pigs intramuscularly every 3 weeks, for either 7 or 14 months. The histopathology of the prostate was described. Epithelial hyperplasia was found in 14/21 animals receiving testosterone and in 7/12 very old animals, but no such changes were found in the sham or castrated animals. Testosterone stimulation seems to induce epithelial hyperplasia, but not cancer, in the guinea-pig prostate.

Original language	English
Pages (from-to)	227-231
Journal	Prostate Cancer and Prostatic Diseases
Volume	7
Issue number	3
DOIs	https://doi.org/10.1038/sj.pcan.4500744
Publication status	Published - 2004

Subject classification (UKÄ)

Obstetrics, Gynecology and Reproductive Medicine

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/sj.pcan.4500744

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title = "Long-term testosterone stimulation induces hyperplasia in the guinea-pig prostate.",

abstract = "The relation between supraphysiologic circulating testosterone levels and prostatic diseases is unclear and difficult to study in men. Animal models may be advantageous. Based on a pilot study, testosterone enantate 50 mg (n=12) or 25 mg (n=12) was administered to guinea-pigs intramuscularly every 3 weeks, for either 7 or 14 months. The histopathology of the prostate was described. Epithelial hyperplasia was found in 14/21 animals receiving testosterone and in 7/12 very old animals, but no such changes were found in the sham or castrated animals. Testosterone stimulation seems to induce epithelial hyperplasia, but not cancer, in the guinea-pig prostate.",

author = "Stefan Acosta and Nishtman Dizeyi and R Feinstein and Stefan Pierzynowski and Per-Anders Abrahamsson",

year = "2004",

doi = "10.1038/sj.pcan.4500744",

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T1 - Long-term testosterone stimulation induces hyperplasia in the guinea-pig prostate.

AU - Acosta, Stefan

AU - Dizeyi, Nishtman

AU - Feinstein, R

AU - Pierzynowski, Stefan

AU - Abrahamsson, Per-Anders

PY - 2004

Y1 - 2004

N2 - The relation between supraphysiologic circulating testosterone levels and prostatic diseases is unclear and difficult to study in men. Animal models may be advantageous. Based on a pilot study, testosterone enantate 50 mg (n=12) or 25 mg (n=12) was administered to guinea-pigs intramuscularly every 3 weeks, for either 7 or 14 months. The histopathology of the prostate was described. Epithelial hyperplasia was found in 14/21 animals receiving testosterone and in 7/12 very old animals, but no such changes were found in the sham or castrated animals. Testosterone stimulation seems to induce epithelial hyperplasia, but not cancer, in the guinea-pig prostate.

AB - The relation between supraphysiologic circulating testosterone levels and prostatic diseases is unclear and difficult to study in men. Animal models may be advantageous. Based on a pilot study, testosterone enantate 50 mg (n=12) or 25 mg (n=12) was administered to guinea-pigs intramuscularly every 3 weeks, for either 7 or 14 months. The histopathology of the prostate was described. Epithelial hyperplasia was found in 14/21 animals receiving testosterone and in 7/12 very old animals, but no such changes were found in the sham or castrated animals. Testosterone stimulation seems to induce epithelial hyperplasia, but not cancer, in the guinea-pig prostate.

U2 - 10.1038/sj.pcan.4500744

DO - 10.1038/sj.pcan.4500744

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JO - Prostate Cancer and Prostatic Diseases

JF - Prostate Cancer and Prostatic Diseases

IS - 3

ER -

Long-term testosterone stimulation induces hyperplasia in the guinea-pig prostate.

Abstract

Subject classification (UKÄ)

UN SDGs

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