Loss of the tumor suppressor gene AIP mediates the browning of human brown fat tumors

Linda Magnusson, Nils Hansen, Karim H Saba, Jenny Nilsson, Thoas Fioretos, Pehr Rissler, Karolin Hansén Nord

Research output: Contribution to journalArticlepeer-review

Abstract

Human brown fat tumors (hibernomas) display concomitant loss of the tumor suppressor genes MEN1 and AIP. In the present study, we hypothesized that the brown fat phenotype is attributed to these mutations. Accordingly, we demonstrate that silencing of AIP in human brown preadipocytic and white fat cell lines results in the induction of the brown fat marker UCP1. In human adipocytic tumors, loss of MEN1 was found both in white (one out of 51 lipomas) and brown fat tumors. In contrast, concurrent loss of AIP was always accompanied by a brown fat morphology. We conclude that this white-to-brown phenotype switch in brown fat tumors is mediated by the loss of AIP.

Original languageEnglish
Pages (from-to)160-164
JournalJournal of Pathology
Volume243
Issue number2
DOIs
Publication statusPublished - 2017 Oct

Subject classification (UKÄ)

  • Medical Genetics
  • Cancer and Oncology

Free keywords

  • Journal Article

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