Low elastin content of carotid plaques is associated with increased risk of ipsilateral stroke.

Giuseppe Asciutto; Nuno Dias; Andreas Edsfeldt; Mihaela Nitulescu; Ana Persson; Marie MN Nilsson; Pontus Dunér; Jan Nilsson; Isabel Goncalves

doi:10.1371/journal.pone.0121086

Low elastin content of carotid plaques is associated with increased risk of ipsilateral stroke.

Giuseppe Asciutto, Nuno Dias, Andreas Edsfeldt, Mihaela Nitulescu, Ana Persson, Marie MN Nilsson, Pontus Dunér, Jan Nilsson, Isabel Goncalves

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Abstract

Atherosclerotic plaques with a low content of connective tissue proteins are believed to have an increased risk of rupture and to give rise to clinical events. The aim of the present study was to investigate if the content of elastin, collagen and of the matrix metalloproteinase (MMP) -1, -3, -9 and -12 in plaques removed at surgery can be associated with the occurrence of ipsilateral symptoms.

Original language	English
Article number	e0121086
Journal	PLoS ONE
Volume	10
Issue number	3
DOIs	https://doi.org/10.1371/journal.pone.0121086
Publication status	Published - 2015

Subject classification (UKÄ)

Cardiology and Cardiovascular Disease

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http://www.ncbi.nlm.nih.gov/pubmed/25803692?dopt=Abstract

Cite this

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title = "Low elastin content of carotid plaques is associated with increased risk of ipsilateral stroke.",

abstract = "Atherosclerotic plaques with a low content of connective tissue proteins are believed to have an increased risk of rupture and to give rise to clinical events. The aim of the present study was to investigate if the content of elastin, collagen and of the matrix metalloproteinase (MMP) -1, -3, -9 and -12 in plaques removed at surgery can be associated with the occurrence of ipsilateral symptoms.",

author = "Giuseppe Asciutto and Nuno Dias and Andreas Edsfeldt and Mihaela Nitulescu and Ana Persson and Nilsson, {Marie MN} and Pontus Dun{\'e}r and Jan Nilsson and Isabel Goncalves",

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AU - Asciutto, Giuseppe

AU - Dias, Nuno

AU - Edsfeldt, Andreas

AU - Nitulescu, Mihaela

AU - Persson, Ana

AU - Nilsson, Marie MN

AU - Dunér, Pontus

AU - Nilsson, Jan

AU - Goncalves, Isabel

PY - 2015

Y1 - 2015

N2 - Atherosclerotic plaques with a low content of connective tissue proteins are believed to have an increased risk of rupture and to give rise to clinical events. The aim of the present study was to investigate if the content of elastin, collagen and of the matrix metalloproteinase (MMP) -1, -3, -9 and -12 in plaques removed at surgery can be associated with the occurrence of ipsilateral symptoms.

AB - Atherosclerotic plaques with a low content of connective tissue proteins are believed to have an increased risk of rupture and to give rise to clinical events. The aim of the present study was to investigate if the content of elastin, collagen and of the matrix metalloproteinase (MMP) -1, -3, -9 and -12 in plaques removed at surgery can be associated with the occurrence of ipsilateral symptoms.

U2 - 10.1371/journal.pone.0121086

DO - 10.1371/journal.pone.0121086

M3 - Article

C2 - 25803692

SN - 1932-6203

VL - 10

JO - PLoS ONE

JF - PLoS ONE

IS - 3

M1 - e0121086

ER -

Low elastin content of carotid plaques is associated with increased risk of ipsilateral stroke.

Abstract

Subject classification (UKÄ)

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