Low Free Testosterone is Associated with Hypogonadal Signs and Symptoms in Men with Normal Total Testosterone.

Leen Antonio; Frederick C W Wu; Terence W O'Neill; Stephen R Pye; Tomas B Ahern; Michaël R Laurent; Ilpo T Huhtaniemi; Michael E J Lean; Brian G Keevil; Giulia Rastrelli; Gianni Forti; György Bartfai; Felipe F Casanueva; Krzysztof Kula; Margus Punab; Aleksander Giwercman; Frank Claessens; Brigitte Decallonne; Dirk Vanderschueren

doi:10.1210/jc.2015-4106

Low Free Testosterone is Associated with Hypogonadal Signs and Symptoms in Men with Normal Total Testosterone.

Leen Antonio, Frederick C W Wu, Terence W O'Neill, Stephen R Pye, Tomas B Ahern, Michaël R Laurent, Ilpo T Huhtaniemi, Michael E J Lean, Brian G Keevil, Giulia Rastrelli, Gianni Forti, György Bartfai, Felipe F Casanueva, Krzysztof Kula, Margus Punab, Aleksander Giwercman, Frank Claessens, Brigitte Decallonne, Dirk Vanderschueren

Reproductive medicine, Malmö

University Hospitals Leuven

Research output: Contribution to journal › Article › peer-review

Abstract

During ageing, total testosterone (TT) declines and SHBG increases, resulting in a greater decrease in calculated free testosterone (cFT). Currently, guidelines suggest using TT to diagnose androgen deficiency and to reserve cFT only for men with borderline TT.

Original language	English
Pages (from-to)	2647-2657
Journal	The Journal of clinical endocrinology and metabolism
Volume	101
Issue number	7
DOIs	https://doi.org/10.1210/jc.2015-4106
Publication status	Published - 2016

Subject classification (UKÄ)

Endocrinology and Diabetes

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10.1210/jc.2015-4106

http://www.ncbi.nlm.nih.gov/pubmed/26909800?dopt=Abstract

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Antonio, L., Wu, F. C. W., O'Neill, T. W., Pye, S. R., Ahern, T. B., Laurent, M. R., Huhtaniemi, I. T., Lean, M. E. J., Keevil, B. G., Rastrelli, G., Forti, G., Bartfai, G., Casanueva, F. F., Kula, K., Punab, M., Giwercman, A., Claessens, F., Decallonne, B., & Vanderschueren, D. (2016). Low Free Testosterone is Associated with Hypogonadal Signs and Symptoms in Men with Normal Total Testosterone. The Journal of clinical endocrinology and metabolism, 101(7), 2647-2657. https://doi.org/10.1210/jc.2015-4106

@article{2a22ff4e3b724c2d9e978cb33efa637d,

title = "Low Free Testosterone is Associated with Hypogonadal Signs and Symptoms in Men with Normal Total Testosterone.",

abstract = "During ageing, total testosterone (TT) declines and SHBG increases, resulting in a greater decrease in calculated free testosterone (cFT). Currently, guidelines suggest using TT to diagnose androgen deficiency and to reserve cFT only for men with borderline TT.",

author = "Leen Antonio and Wu, {Frederick C W} and O'Neill, {Terence W} and Pye, {Stephen R} and Ahern, {Tomas B} and Laurent, {Micha{\"e}l R} and Huhtaniemi, {Ilpo T} and Lean, {Michael E J} and Keevil, {Brian G} and Giulia Rastrelli and Gianni Forti and Gy{\"o}rgy Bartfai and Casanueva, {Felipe F} and Krzysztof Kula and Margus Punab and Aleksander Giwercman and Frank Claessens and Brigitte Decallonne and Dirk Vanderschueren",

year = "2016",

doi = "10.1210/jc.2015-4106",

language = "English",

volume = "101",

pages = "2647--2657",

journal = "The Journal of clinical endocrinology and metabolism",

issn = "1945-7197",

publisher = "Oxford University Press",

number = "7",

}

Antonio, L, Wu, FCW, O'Neill, TW, Pye, SR, Ahern, TB, Laurent, MR, Huhtaniemi, IT, Lean, MEJ, Keevil, BG, Rastrelli, G, Forti, G, Bartfai, G, Casanueva, FF, Kula, K, Punab, M, Giwercman, A, Claessens, F, Decallonne, B & Vanderschueren, D 2016, 'Low Free Testosterone is Associated with Hypogonadal Signs and Symptoms in Men with Normal Total Testosterone.', The Journal of clinical endocrinology and metabolism, vol. 101, no. 7, pp. 2647-2657. https://doi.org/10.1210/jc.2015-4106

TY - JOUR

T1 - Low Free Testosterone is Associated with Hypogonadal Signs and Symptoms in Men with Normal Total Testosterone.

AU - Antonio, Leen

AU - Wu, Frederick C W

AU - O'Neill, Terence W

AU - Pye, Stephen R

AU - Ahern, Tomas B

AU - Laurent, Michaël R

AU - Huhtaniemi, Ilpo T

AU - Lean, Michael E J

AU - Keevil, Brian G

AU - Rastrelli, Giulia

AU - Forti, Gianni

AU - Bartfai, György

AU - Casanueva, Felipe F

AU - Kula, Krzysztof

AU - Punab, Margus

AU - Giwercman, Aleksander

AU - Claessens, Frank

AU - Decallonne, Brigitte

AU - Vanderschueren, Dirk

PY - 2016

Y1 - 2016

N2 - During ageing, total testosterone (TT) declines and SHBG increases, resulting in a greater decrease in calculated free testosterone (cFT). Currently, guidelines suggest using TT to diagnose androgen deficiency and to reserve cFT only for men with borderline TT.

AB - During ageing, total testosterone (TT) declines and SHBG increases, resulting in a greater decrease in calculated free testosterone (cFT). Currently, guidelines suggest using TT to diagnose androgen deficiency and to reserve cFT only for men with borderline TT.

U2 - 10.1210/jc.2015-4106

DO - 10.1210/jc.2015-4106

M3 - Article

C2 - 26909800

SN - 1945-7197

VL - 101

SP - 2647

EP - 2657

JO - The Journal of clinical endocrinology and metabolism

JF - The Journal of clinical endocrinology and metabolism

IS - 7

ER -

Low Free Testosterone is Associated with Hypogonadal Signs and Symptoms in Men with Normal Total Testosterone.

Abstract

Subject classification (UKÄ)

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