Low-level exposure to polycyclic aromatic hydrocarbons is associated with reduced lung function among Swedish young adults

Ayman Alhamdow, Anna Zettergren, Inger Kull, Jenny Hallberg, Niklas Andersson, Sandra Ekström, Marika Berglund, Craig E. Wheelock, Yona J. Essig, Annette M. Krais, Antonios Georgelis, Christian H. Lindh, Erik Melén, Anna Bergström

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Exposure to polycyclic aromatic hydrocarbons (PAHs) has been linked to adverse pulmonary effects. However, the impact of low-level environmental PAH exposure on lung function in early adulthood remains uncertain. Objectives: To evaluate the associations between urinary PAH metabolites and lung function parameters in young adults. Methods: Urinary metabolites of pyrene, phenanthrene, and fluorene were analysed in 1000 young adults from Sweden (age 22–25 years) using LC-MS/MS. Lung function and eosinophilic airway inflammation were measured by spirometry and exhaled nitric oxide fraction (FeNO), respectively. Linear regression analysis was used to evaluate associations between PAH metabolites and the outcomes. Results: Median urinary concentrations of 1-OH-pyrene, ∑OH-phenanthrene, and ∑OH-fluorene were 0.066, 0.36, 0.22 μg/L, respectively. We found inverse associations of ∑OH-phenanthrene and ∑OH-fluorene with FEV1 and FVC, as well as between 1-OH-pyrene and FEV1/FVC ratio (adjusted P < 0.05; all participants). An increase of 1% in ∑OH-fluorene was associated with a decrease of 73 mL in FEV1 and 59 mL in FVC. In addition, ∑OH-phenanthrene concentrations were, in a dose-response manner, inversely associated with FEV1 (B from −109 to −48 compared with the lowest quartile of ∑OH-phenanthrene; p trend 0.004) and FVC (B from −159 to −102 compared with lowest quartile; p-trend <0.001). Similar dose-response associations were also observed between ∑OH-fluorene and FEV1 and FVC, as well as between 1-OH-pyrene and FEV1/FVC (p-trend <0.05). There was no association between PAH exposure and FeNO, nor was there an interaction with smoking, sex, or asthma. Conclusion: Low-level PAH exposure was, in a dose-response manner, associated with reduced lung function in young adults. Our findings have public health implications due to i) the widespread occurrence of PAHs in the environment and ii) the clinical relevance of lung function in predicting all-cause and cardiovascular disease mortality.

Original languageEnglish
Article number111169
JournalEnvironmental Research
Volume197
DOIs
Publication statusPublished - 2021 Jun

Subject classification (UKÄ)

  • Respiratory Medicine and Allergy

Free keywords

  • Air pollution
  • Asthma
  • Environmental exposure
  • Polycyclic aromatic hydrocarbons
  • Urinary metabolites

Fingerprint

Dive into the research topics of 'Low-level exposure to polycyclic aromatic hydrocarbons is associated with reduced lung function among Swedish young adults'. Together they form a unique fingerprint.

Cite this