TY - JOUR
T1 - Lower spatial QRS-T angle rules out sustained ventricular arrhythmias in children with hypertrophic cardiomyopathy
AU - Cortez, Daniel
AU - Sharma, Nandita
AU - Cavanaugh, Jean
AU - Tuozo, Froilan
AU - Derk, Gwendolyn
AU - Lundberg, Emily
AU - Weiner, Keith
AU - Kiciman, Nafiz
AU - Alejos, Juan
AU - Landeck, Bruce
AU - Aboulhosn, Jamil
AU - Miyamoto, Shelley
AU - McCanta, Anthony C.
AU - Batra, Anjan S.
PY - 2017
Y1 - 2017
N2 - Introduction: The spatial peaks QRS-T angle accurately distinguishes children with hypertrophic cardiomyopathy from their healthy counterparts. The spatial peaks QRS-T angle is also useful in risk stratification for ventricular arrhythmias. We hypothesised that the spatial peaks QRS-T angle would be useful for the prediction of ventricular arrhythmias in hypertrophic cardiomyopathy patients under 23 years of age. Methods: Corrected QT interval and spatial peaks QRS-T angles were retrospectively assessed in 133 paediatric hypertrophic cardiomyopathy patients (12.4±6.6 years) with versus without ventricular arrhythmias of 30 seconds or longer. Significance, positive/negative predictive values, and odds ratios were calculated based on receiver operating characteristic curve cut-off values. Results: In total, 10 patients with ventricular arrhythmias were identified. Although the corrected QT interval did not differentiate those with versus without ventricular arrhythmias, the spatial peaks QRS-T angle did (151.4±19.0 versus 116.8±42.6 degrees, respectively, p<0.001). At an optimal cut-off value (124.1 degrees), the positive and negative predictive values of the spatial peaks QRS-T angle were 15.4 and 100.0%, respectively, with an odds ratio of 25.9 (95% CI 1.5–452.2). Conclusion: In children with hypertrophic cardiomyopathy, the spatial peaks QRS-T angle is associated with ventricular arrhythmia burden with high negative predictive value and odds ratio.
AB - Introduction: The spatial peaks QRS-T angle accurately distinguishes children with hypertrophic cardiomyopathy from their healthy counterparts. The spatial peaks QRS-T angle is also useful in risk stratification for ventricular arrhythmias. We hypothesised that the spatial peaks QRS-T angle would be useful for the prediction of ventricular arrhythmias in hypertrophic cardiomyopathy patients under 23 years of age. Methods: Corrected QT interval and spatial peaks QRS-T angles were retrospectively assessed in 133 paediatric hypertrophic cardiomyopathy patients (12.4±6.6 years) with versus without ventricular arrhythmias of 30 seconds or longer. Significance, positive/negative predictive values, and odds ratios were calculated based on receiver operating characteristic curve cut-off values. Results: In total, 10 patients with ventricular arrhythmias were identified. Although the corrected QT interval did not differentiate those with versus without ventricular arrhythmias, the spatial peaks QRS-T angle did (151.4±19.0 versus 116.8±42.6 degrees, respectively, p<0.001). At an optimal cut-off value (124.1 degrees), the positive and negative predictive values of the spatial peaks QRS-T angle were 15.4 and 100.0%, respectively, with an odds ratio of 25.9 (95% CI 1.5–452.2). Conclusion: In children with hypertrophic cardiomyopathy, the spatial peaks QRS-T angle is associated with ventricular arrhythmia burden with high negative predictive value and odds ratio.
KW - hypertrophic cardiomyopathy
KW - prediction
KW - QTc
KW - Spatial QRS-T angle
KW - ventricular arrhythmias
UR - http://www.scopus.com/inward/record.url?scp=84973917046&partnerID=8YFLogxK
U2 - 10.1017/S1047951116000640
DO - 10.1017/S1047951116000640
M3 - Article
C2 - 27246458
AN - SCOPUS:84973917046
SN - 1047-9511
VL - 27
SP - 354
EP - 358
JO - Cardiology in the Young
JF - Cardiology in the Young
IS - 2
ER -