Lung deposition of surfactant delivered via a dedicated laryngeal mask airway in piglets

Anders Nord, Doris Cunha-Goncalves, Rikard Linnér, Federico Bianco, Fabrizio Salomone, Francesca Ricci, Marta Lombardini, Massimo Micaglio, Daniele Trevisanuto, Valeria Perez-De-sa

Research output: Contribution to journalArticlepeer-review


It is unknown if the lung deposition of surfactant administered via a catheter placed through a laryngeal mask airway (LMA) is equivalent to that obtained by bolus instillation through an endotracheal tube. We compare the lung deposition of surfactant delivered via two types of LMA with the standard technique of endotracheal instillation. 25 newborn piglets on continuous positive airway pressure support (CPAP) were randomized into three groups: 1—LMA-camera (integrated camera and catheter channel; catheter tip below vocal cords), 2—LMA-standard (no camera, no channel; catheter tip above the glottis), 3—InSurE (Intubation, Surfactant administration, Extubation; catheter tip below end of endotracheal tube). All animals received 100 mg·kg−1 of poractant alfa mixed with99mTechnetium-nanocolloid. Surfactant deposition was measured by gamma scintigraphy as a percentage of the administered dose. The median (range) total lung surfactant deposition was 68% (10–85), 41% (5–88), and 88% (67–92) in LMA-camera, LMA-standard, and InSurE, respectively, which was higher (p < 0.05) in the latter. The deposition in the stomach and nasopharynx was higher with the LMA-standard. The surfactant deposition via an LMA was lower than that obtained with InSurE. Although not statistically significant, introducing the catheter below the vocal cords under visual control with an integrated camera improved surfactant LMA delivery by 65%.

Original languageEnglish
Article number1858
Issue number11
Publication statusPublished - 2021 Nov

Subject classification (UKÄ)

  • Anesthesiology and Intensive Care
  • Respiratory Medicine and Allergy

Free keywords

  • Laryngeal mask airway
  • Lung deposition
  • Newborn
  • Scintigraphy
  • Surfactant


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