Magnetic CLEAR supports for solid-phase synthesis of peptides and small organic molecules

Pottayil Sasikumar, Maria Kempe

Research output: Contribution to journalArticlepeer-review


Paramagnetic versions of the CLEAR supports were prepared by entrapment of magnetite particles during suspension polymerization of allylamine, trimethylolpropane ethoxylate (14/3 EO/OH) triacrylate, and trimethylolpropane trimethacrylate. Swelling studies in a broad range of solvents showed comparable swelling of magnetic beads and regular CLEAR beads. The application of the magnetic beads as the support in solid-phase synthesis of peptides (Leu-enkephalinamide, substance P, acyl carrier protein (65-74) amide, and amyloid beta-protein (34-42) amide) and small organic affinity ligands based on the s-triazine scaffold was demonstrated. Adequate stability of the beads and retention of their magnetic properties were observed throughout the synthesis steps.
Original languageEnglish
Pages (from-to)129-141
JournalInternational Journal of Peptide Research and Therapeutics
Issue number1-2
Publication statusPublished - 2007

Subject classification (UKÄ)

  • Pharmacology and Toxicology

Free keywords

  • suspension polymerization
  • substance P
  • s-triazine scaffold
  • synthesis
  • solid-phase
  • resin
  • magnetite
  • magnetic support
  • Leu-enkephalin
  • acyl carrier protein (65-74)
  • amyloid beta-protein (34-42)


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