Maintenance of susceptibility to neurodegeneration following intrastriatal injections of quinolinic acid in a new transgenic mouse model of Huntington's disease.

Åsa Petersén, K Chase, Zoe Puschban, M DiFiglia, Patrik Brundin, N Aronin

Research output: Contribution to journalArticlepeer-review

Abstract

A transgenic mouse model of Huntington's disease (R6/1 and R6/2 lines) expressing exon 1 of the HD gene with 115-150 CAG repeats resisted striatal damage following injection of quinolinic acid and other neurotoxins. We examined whether excitotoxin resistance characterizes mice with mutant huntingtin transgenes. In a new transgenic mouse with 3 kb of mutant human huntingtin cDNA with 18, 46, or 100 CAG repeats, we found no change in susceptibility to intrastriatal injections of the excitotoxin quinolinic acid, compared to wild-type littermates. The new transgenic mice were injected with the same dose of quinolinic acid (30 nmol) as had been the R6 mice. Our findings highlight the importance of studying pathogenetic mechanisms in different transgenic models of a disease.
Original languageEnglish
Pages (from-to)297-300
JournalExperimental Neurology
Volume175
Issue number1
DOIs
Publication statusPublished - 2002

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Neuronal Survival (013212041)

Subject classification (UKÄ)

  • Neurology

Free keywords

  • Huntington Disease : complications
  • Heterozygote
  • Huntington Disease : chemically induced
  • Human
  • Huntington Disease : genetics
  • P.H.S.
  • U.S. Gov't
  • Support
  • Non-P.H.S.
  • Non-U.S. Gov't
  • Species Specificity
  • Quinolinic Acid : administration & dosage
  • Neurons : pathology
  • Neurons : drug effects
  • Neurodegenerative Diseases : pathology
  • Neurodegenerative Diseases : complications
  • Neurodegenerative Diseases : chemically induced
  • Microinjections
  • Transgenic
  • Mice
  • Huntington Disease : pathology
  • Disease Susceptibility
  • Animal
  • Disease Models
  • Corpus Striatum : pathology
  • Cell Count
  • Cell Death
  • Corpus Striatum : drug effects

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