Male infertility

Michael L. Eisenberg; Sandro C. Esteves; Dolores J. Lamb; James M. Hotaling; Aleksander Giwercman; Kathleen Hwang; Yu Sheng Cheng

doi:10.1038/s41572-023-00459-w

Male infertility

Michael L. Eisenberg, Sandro C. Esteves, Dolores J. Lamb, James M. Hotaling, Aleksander Giwercman, Kathleen Hwang, Yu Sheng Cheng

Research output: Contribution to journal › Review article › peer-review

Abstract

Clinical infertility is the inability of a couple to conceive after 12 months of trying. Male factors are estimated to contribute to 30–50% of cases of infertility. Infertility or reduced fertility can result from testicular dysfunction, endocrinopathies, lifestyle factors (such as tobacco and obesity), congenital anatomical factors, gonadotoxic exposures and ageing, among others. The evaluation of male infertility includes detailed history taking, focused physical examination and selective laboratory testing, including semen analysis. Treatments include lifestyle optimization, empirical or targeted medical therapy as well as surgical therapies that lead to measurable improvement in fertility. Although male infertility is recognized as a disease with effects on quality of life for both members of the infertile couple, fewer data exist on specific quantification and impact compared with other health-related conditions.

Original language	English
Article number	49
Journal	Nature Reviews Disease Primers
Volume	9
Issue number	1
DOIs	https://doi.org/10.1038/s41572-023-00459-w
Publication status	Published - 2023 Dec

Subject classification (UKÄ)

Obstetrics, Gynecology and Reproductive Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41572-023-00459-w

Cite this

@article{e95ce2d69ccb488ea077aa7f618f4292,

title = "Male infertility",

abstract = "Clinical infertility is the inability of a couple to conceive after 12 months of trying. Male factors are estimated to contribute to 30–50% of cases of infertility. Infertility or reduced fertility can result from testicular dysfunction, endocrinopathies, lifestyle factors (such as tobacco and obesity), congenital anatomical factors, gonadotoxic exposures and ageing, among others. The evaluation of male infertility includes detailed history taking, focused physical examination and selective laboratory testing, including semen analysis. Treatments include lifestyle optimization, empirical or targeted medical therapy as well as surgical therapies that lead to measurable improvement in fertility. Although male infertility is recognized as a disease with effects on quality of life for both members of the infertile couple, fewer data exist on specific quantification and impact compared with other health-related conditions.",

author = "Eisenberg, {Michael L.} and Esteves, {Sandro C.} and Lamb, {Dolores J.} and Hotaling, {James M.} and Aleksander Giwercman and Kathleen Hwang and Cheng, {Yu Sheng}",

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year = "2023",

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doi = "10.1038/s41572-023-00459-w",

language = "English",

volume = "9",

journal = "Nature Reviews Disease Primers",

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TY - JOUR

T1 - Male infertility

AU - Eisenberg, Michael L.

AU - Esteves, Sandro C.

AU - Lamb, Dolores J.

AU - Hotaling, James M.

AU - Giwercman, Aleksander

AU - Hwang, Kathleen

AU - Cheng, Yu Sheng

PY - 2023/12

Y1 - 2023/12

N2 - Clinical infertility is the inability of a couple to conceive after 12 months of trying. Male factors are estimated to contribute to 30–50% of cases of infertility. Infertility or reduced fertility can result from testicular dysfunction, endocrinopathies, lifestyle factors (such as tobacco and obesity), congenital anatomical factors, gonadotoxic exposures and ageing, among others. The evaluation of male infertility includes detailed history taking, focused physical examination and selective laboratory testing, including semen analysis. Treatments include lifestyle optimization, empirical or targeted medical therapy as well as surgical therapies that lead to measurable improvement in fertility. Although male infertility is recognized as a disease with effects on quality of life for both members of the infertile couple, fewer data exist on specific quantification and impact compared with other health-related conditions.

AB - Clinical infertility is the inability of a couple to conceive after 12 months of trying. Male factors are estimated to contribute to 30–50% of cases of infertility. Infertility or reduced fertility can result from testicular dysfunction, endocrinopathies, lifestyle factors (such as tobacco and obesity), congenital anatomical factors, gonadotoxic exposures and ageing, among others. The evaluation of male infertility includes detailed history taking, focused physical examination and selective laboratory testing, including semen analysis. Treatments include lifestyle optimization, empirical or targeted medical therapy as well as surgical therapies that lead to measurable improvement in fertility. Although male infertility is recognized as a disease with effects on quality of life for both members of the infertile couple, fewer data exist on specific quantification and impact compared with other health-related conditions.

U2 - 10.1038/s41572-023-00459-w

DO - 10.1038/s41572-023-00459-w

M3 - Review article

C2 - 37709866

AN - SCOPUS:85171298902

SN - 2056-676X

VL - 9

JO - Nature Reviews Disease Primers

JF - Nature Reviews Disease Primers

IS - 1

M1 - 49

ER -

Male infertility

Abstract

Subject classification (UKÄ)

UN SDGs

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