Malignant hyperthermia, a Scandinavian update.

Marcus Ewert Broman; Gunilla Islander; C R Müller

doi:10.1111/aas.12541

Malignant hyperthermia, a Scandinavian update.

Marcus Ewert Broman, Gunilla Islander, C R Müller

Research output: Contribution to journal › Review article › peer-review

Abstract

Malignant Hyperthermia (MH) is a rare pharmacogenetic disorder, triggered by halogenated anesthetics and/or succinylcholine. In susceptible individuals, these drugs can activate an explosive life threatening clinical reaction. Leading symptoms are hypercarbia, muscle rigidity, and metabolic acidosis. MH is inherited in an autosomal-dominant manner and linked to mutations in the large ryanodine 1 gene (RYR1) gene in the majority of cases. Very few MH patients have been found to carry mutations in the CACNA1S gene.

Original language	English
Pages (from-to)	951-961
Journal	Acta Anaesthesiologica Scandinavica
Volume	59
Issue number	8
DOIs	https://doi.org/10.1111/aas.12541
Publication status	Published - 2015

Subject classification (UKÄ)

Anesthesiology and Intensive Care

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10.1111/aas.12541

http://www.ncbi.nlm.nih.gov/pubmed/25989378?dopt=Abstract

Cite this

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title = "Malignant hyperthermia, a Scandinavian update.",

abstract = "Malignant Hyperthermia (MH) is a rare pharmacogenetic disorder, triggered by halogenated anesthetics and/or succinylcholine. In susceptible individuals, these drugs can activate an explosive life threatening clinical reaction. Leading symptoms are hypercarbia, muscle rigidity, and metabolic acidosis. MH is inherited in an autosomal-dominant manner and linked to mutations in the large ryanodine 1 gene (RYR1) gene in the majority of cases. Very few MH patients have been found to carry mutations in the CACNA1S gene.",

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AU - Broman, Marcus Ewert

AU - Islander, Gunilla

AU - Müller, C R

PY - 2015

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N2 - Malignant Hyperthermia (MH) is a rare pharmacogenetic disorder, triggered by halogenated anesthetics and/or succinylcholine. In susceptible individuals, these drugs can activate an explosive life threatening clinical reaction. Leading symptoms are hypercarbia, muscle rigidity, and metabolic acidosis. MH is inherited in an autosomal-dominant manner and linked to mutations in the large ryanodine 1 gene (RYR1) gene in the majority of cases. Very few MH patients have been found to carry mutations in the CACNA1S gene.

AB - Malignant Hyperthermia (MH) is a rare pharmacogenetic disorder, triggered by halogenated anesthetics and/or succinylcholine. In susceptible individuals, these drugs can activate an explosive life threatening clinical reaction. Leading symptoms are hypercarbia, muscle rigidity, and metabolic acidosis. MH is inherited in an autosomal-dominant manner and linked to mutations in the large ryanodine 1 gene (RYR1) gene in the majority of cases. Very few MH patients have been found to carry mutations in the CACNA1S gene.

U2 - 10.1111/aas.12541

DO - 10.1111/aas.12541

M3 - Review article

C2 - 25989378

SN - 0001-5172

VL - 59

SP - 951

EP - 961

JO - Acta Anaesthesiologica Scandinavica

JF - Acta Anaesthesiologica Scandinavica

IS - 8

ER -

Malignant hyperthermia, a Scandinavian update.

Abstract

Subject classification (UKÄ)

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