Mapping prostatic microscopic anisotropy using linear and spherical b-tensor encoding: A preliminary study

Purpose: Tensor-valued diffusion encoding provides more specific information than conventional diffusion-weighted imaging (DWI), but has mainly been applied in neuroimaging studies. This study aimed to assess its potential for the imaging of prostate cancer (PCa). Methods: Seventeen patients with histologically proven PCa were enrolled. DWI of the prostate was performed with linear and spherical tensor encoding using a maximal b-value of 1.5 ms/µm² and a voxel size of 3 × 3 × 4 mm³. The gamma-distribution model was used to estimate the mean diffusivity (MD), the isotropic kurtosis (MK_I), and the anisotropic kurtosis (MK_A). Regions of interest were placed in MR-defined cancerous tissues, as well as in apparently healthy tissues in the peripheral and transitional zones (PZs and TZs). Results: DWI with linear and spherical encoding yielded different image contrasts at high b-values, which enabled the estimation of MK_A and MK_I. Compared with healthy tissue (PZs and TZs combined) the cancers displayed a significantly lower MD (P <.05), higher MK_I (P < 10⁻⁵), and lower MK_A (P <.05). Compared with the TZ, tissue in the PZ showed lower MD (P < 10⁻³) and higher MK_A (P < 10⁻³). No significant differences were found between cancers of different Gleason scores, possibly because of the limited sample size. Conclusion: Tensor-valued diffusion encoding enabled mapping of MK_A and MK_I in the prostate. The elevated MK_I in PCa compared with normal tissues suggests an elevated heterogeneity in the cancers. Increased in-plane resolution could improve tumor delineation in future studies.