Abstract
In this issue of J Endocrinol, Schuyler et al. show that intimal lesions in atherosclerosis-prone diabetic apoE-/- mice are reduced by insulin treatment. An increase of metalloproteinase-9 expression was observed in untreated diabetic apoE-/- mice; this was absent in insulin-treated mice. The study suggests that hindering of tissue-remodeling metalloproteinases may account for the beneficial effects of proper metabolic control in patients with diabetes. This clinically relevant finding prompts further exploration.
| Original language | English |
|---|---|
| Pages (from-to) | 1-2 |
| Journal | Journal of Endocrinology |
| Volume | 210 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2011 |
Subject classification (UKÄ)
- Endocrinology and Diabetes
