Meandering nanochannels for imaging of ultra-long DNA molecules

C. Freitag, J. Fritzsche, F. Persson, Kalim U. Mir, J. O. Tegenfeldt

Research output: Chapter in Book/Report/Conference proceedingPaper in conference proceedingResearchpeer-review

Abstract

A new chip design for handling and studying chromosomal DNA is described. Folding the nanochannels enables us to image an entire yeast chromosome in a single field of view. Together with existing mapping techniques our new design opens up the possibility of directly analyzing entire chromosomes in a single field of view using fluorescence microscopy. This would enable, for example, identification of microorganisms on a single-cell basis and the complete physical mapping of the human genome, chromosome by chromosome.

Original languageEnglish
Title of host publication15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Pages1758-1760
Number of pages3
Volume3
Publication statusPublished - 2011 Dec 1
Event15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 - Seattle, WA, United States
Duration: 2011 Oct 22011 Oct 6

Conference

Conference15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Country/TerritoryUnited States
CitySeattle, WA
Period2011/10/022011/10/06

Subject classification (UKÄ)

  • Medical Genetics
  • Cell Biology

Keywords

  • Chromosomal DNA
  • DNA analysis
  • Genomics
  • Nanofluidics

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