TY - JOUR
T1 - Measured adiposity in relation to head and neck cancer risk in the European Prospective Investigation into Cancer and Nutrition
AU - Ward, Heather A.
AU - Wark, Petra A.
AU - Muller, David C
AU - Steffen, Annika
AU - Johansson, Mattias
AU - Norat, Teresa
AU - Gunter, Marc J.
AU - Overvad, Kim
AU - Dahm, Christina
AU - Halkjær, Jytte
AU - Tjønneland, Anne
AU - Boutron-Ruault, Marie-Christine
AU - Fagherazzi, Guy
AU - Mesrine, Sylvie
AU - Brennan, Paul
AU - Freisling, Heinz
AU - Li, Kuanrong
AU - Kaaks, Rudolf
AU - Trichopoulou, Antonia
AU - Lagiou, Pagona
AU - Panico, Salvatore
AU - Grioni, Sara
AU - Tumino, Rosario
AU - Vineis, Paolo
AU - Palli, Domenico
AU - Peeters, Petra H. M.
AU - Bueno-de-Mesquita, H. Bas
AU - Weiderpass, Elisabete
AU - Agudo, Antonio
AU - Ramon Quiros, Jose
AU - Larrañaga, Nerea
AU - Ardanaz, Eva
AU - Huerta, José María
AU - Sánchez, María-José
AU - Laurell, Goran
AU - Johansson, Ingegerd
AU - Westin, Ulla
AU - Wallström, Peter
AU - Bradbury, Kathryn E
AU - Wareham, Nicholas J
AU - Khaw, Kay Tee
AU - Pearson, Clare
AU - Boeing, Heiner
AU - Riboli, Elio
N1 - Copyright ©2017, American Association for Cancer Research.
PY - 2017
Y1 - 2017
N2 - BACKGROUND: Emerging evidence from cohort studies indicates that adiposity is associated with greater incidence of head and neck cancer (HNC). However, most studies have used self-reported anthropometry which is prone to error.METHODS: Among 363 094 participants in the European Prospective Investigation into Cancer and Nutrition study (EPIC) with measured anthropometry, there were 837 incident cases of HNC. HNC risk was examined in relation to body mass index (BMI) [lean: < 22.5 kg/m2, normal weight (reference): 22.5-24.9 kg/m2, overweight 25-29.9 kg/m2, obese: > 30 kg/m2], waist circumference (WC), hip circumference (HC) and waist to hip ratio (WHR) using Cox proportional hazards models.RESULTS: Among men, a BMI < 22.5 kg/m2 was associated with higher HNC risk [hazard ratio (HR) 1.62, 95% confidence interval (CI) 1.23 - 2.12)]; BMI was not associated with HNC among women. WC and WHR were associated with greater risk of HNC among women, (WC per 5 cm: HR 1.08, 95% CI 1.02 - 1.15; WHR per 0.1 unit: HR 1.64, 95% CI 1.38 - 1.93). After stratification by smoking status, the association for WHR was present only among smokers (p interaction 0.004). Among men, WC and WHR were associated with HNC only upon additional adjustment for BMI (WC per 5 cm: HR 1.16, 95% CI 1.07 - 1.26; WHR per 0.1 unit: HR 1.42, 95% CI 1.21 - 1.65).CONCLUSION: Central adiposity, particularly among women, may have a stronger association with HNC risk than previously estimated.IMPACT: Strategies to reduce obesity may beneficially impact HNC incidence.
AB - BACKGROUND: Emerging evidence from cohort studies indicates that adiposity is associated with greater incidence of head and neck cancer (HNC). However, most studies have used self-reported anthropometry which is prone to error.METHODS: Among 363 094 participants in the European Prospective Investigation into Cancer and Nutrition study (EPIC) with measured anthropometry, there were 837 incident cases of HNC. HNC risk was examined in relation to body mass index (BMI) [lean: < 22.5 kg/m2, normal weight (reference): 22.5-24.9 kg/m2, overweight 25-29.9 kg/m2, obese: > 30 kg/m2], waist circumference (WC), hip circumference (HC) and waist to hip ratio (WHR) using Cox proportional hazards models.RESULTS: Among men, a BMI < 22.5 kg/m2 was associated with higher HNC risk [hazard ratio (HR) 1.62, 95% confidence interval (CI) 1.23 - 2.12)]; BMI was not associated with HNC among women. WC and WHR were associated with greater risk of HNC among women, (WC per 5 cm: HR 1.08, 95% CI 1.02 - 1.15; WHR per 0.1 unit: HR 1.64, 95% CI 1.38 - 1.93). After stratification by smoking status, the association for WHR was present only among smokers (p interaction 0.004). Among men, WC and WHR were associated with HNC only upon additional adjustment for BMI (WC per 5 cm: HR 1.16, 95% CI 1.07 - 1.26; WHR per 0.1 unit: HR 1.42, 95% CI 1.21 - 1.65).CONCLUSION: Central adiposity, particularly among women, may have a stronger association with HNC risk than previously estimated.IMPACT: Strategies to reduce obesity may beneficially impact HNC incidence.
U2 - 10.1158/1055-9965.EPI-16-0886
DO - 10.1158/1055-9965.EPI-16-0886
M3 - Article
C2 - 28183827
SN - 1538-7755
VL - 26
SP - 895
EP - 904
JO - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
IS - 6
ER -
