Measurement of diffusion coefficients in gels using holographic laser interferometry

N O Gustafsson, B Westrin, Anders Axelsson, Guido Zacchi

Research output: Contribution to journalArticlepeer-review


The accuracy and precision of holographic interferometry as a method to measure diffusion coefficients in gels are investigated both experimentally and theoretically. The standard deviations in the experimentally determined diffusion coefficient for ethanol in 4% (w/v) agarose gel were 3.3% for diffusion into the gel and 6.1% for diffusion out of the gel. These are in good agreement with the standard deviations obtained using Monte Carlo simulations. Systematic errors derived from an assumption of constant diffusion coefficients were also investigated.
Original languageEnglish
Pages (from-to)436-441
JournalBiotechnology Progress
Issue number4
Publication statusPublished - 1993

Subject classification (UKÄ)

  • Chemical Engineering


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